Studies on the nucleic acids of human lymphocytic cells: Acetylation of histones

Studies on the nucleic acids of human lymphocytic cells: Acetylation of histones

Histones have been isolated from human lymphocytic cells in culture and purified through column chromatography. These human lymphocytic cells deriving from various lymphoproliferative diseases incorporate 3H-acetate to differing degrees. Distribution of 3H-acetate label indicated that lysine-rich hi...

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Veröffentlicht in:Archives of biochemistry and biophysics 1970-12, Vol.141 (2), p.552-556
Hauptverfasser: Desai, L.S., Foley, G.E.
Format: Artikel
Sprache:eng
Schlagworte:
Acetates - metabolism
Animals
Arginine
Cell Line
Chromatography, Gel
Cricetinae
Culture Techniques
Female
Histones - metabolism
Humans
Infectious Mononucleosis
Leukemia, Lymphoid
Lymphocytes
Lysine
Male
Tritium
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Zusammenfassung:Histones have been isolated from human lymphocytic cells in culture and purified through column chromatography. These human lymphocytic cells deriving from various lymphoproliferative diseases incorporate 3H-acetate to differing degrees. Distribution of 3H-acetate label indicated that lysine-rich histones were the least, while arginine-rich histones were the most, extensively acetylated.
ISSN:0003-9861
1096-0384
DOI:10.1016/0003-9861(70)90174-8