New Compounds: Potential Antineoplastics VI: 2,4-Diamino-6-hydroxy-5-arylazopyrimidines and 1,3-Dimethyl-5-arylhydrazonoalloxans

A series of 2,4-diamino-6-hydroxy-5-arylazopyrimi-dines and 1,3-dimethyl-5-arylhydrazonoalloxans has been synthesized by the coupling of aryldiazonium salts with 2,4-diamino-6-hydroxypyrimidine and 1,3-dimethylbarbituric acid, respectively. The former are also obtained by the cyclization of ethyl cy...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1970-11, Vol.59 (11), p.1691-1693
Hauptverfasser:	Garg, H.G., Sharma, R.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3-Dimethyl-5-arylhydraz-onoalloxans—synthesis, potential antineoplastics 2.4 - Diamino - 6 - hydroxy - 5 - arylazopyrimidines-synthesis 2.4 – Diamino – 6 – hydroxy – 5 – arylazopyrimidines—synthesis, potential antineoplastics 3-Dimethyl-5-arylhydraz-onoalloxans-synthesis 3-dimethyl-5-arylhydrazonoalloxans Alloxan - chemical synthesis Antineoplastic Agents - chemical synthesis Antineoplastics-2.4-diamino-6-hydroxy-5-arylazopyrimidines Antineoplastics—2.4-diamino-6-hydroxy-5-arylazopyrimidines, 1,3-dimethyl-5-arylhydrazonoalloxans, synthesis Chemical Phenomena Chemistry Methods potential antineoplastics Pyrimidines - chemical synthesis synthesis
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Beschreibung
Zusammenfassung:	A series of 2,4-diamino-6-hydroxy-5-arylazopyrimi-dines and 1,3-dimethyl-5-arylhydrazonoalloxans has been synthesized by the coupling of aryldiazonium salts with 2,4-diamino-6-hydroxypyrimidine and 1,3-dimethylbarbituric acid, respectively. The former are also obtained by the cyclization of ethyl cyano-glyoxalate arylhydrazones and guanidine hydrochloride in the presence of sodium ethoxide.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600591139