THE FREE AMINO ACIDS IN HUMAN CEREBROSPINAL FLUID

—(a) The free amino acids in human cerebrospinal fluid from 78 subjects have been determined by means of ion exchange chromatography. Analyses were performed on 2 to 3 ml of CSF. (b) Normal values are given for a control group of 13 subjects. (c) The presence of homocarnosine in human CSF is ascerta...

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Veröffentlicht in:	Journal of neurochemistry 1970-02, Vol.17 (2), p.125-135
Hauptverfasser:	Sande, M., Mardens, Y., Adriaenssens, K., Lowenthal, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Amino Acids - blood Amino Acids - cerebrospinal fluid Child Child, Preschool Chromatography Dipeptides - cerebrospinal fluid Humans Infant Metabolic Diseases - cerebrospinal fluid Metabolism, Inborn Errors - blood Metabolism, Inborn Errors - cerebrospinal fluid Middle Aged Nervous System Diseases - cerebrospinal fluid Phenylketonurias - cerebrospinal fluid
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Beschreibung
Zusammenfassung:	—(a) The free amino acids in human cerebrospinal fluid from 78 subjects have been determined by means of ion exchange chromatography. Analyses were performed on 2 to 3 ml of CSF. (b) Normal values are given for a control group of 13 subjects. (c) The presence of homocarnosine in human CSF is ascertained. The concentration of this dipeptide is very high in CSF samples from phenylketonuric patients. (d) The CSF amino acid pattern in 20 patients with a metabolic disease is discussed. (e) The CSF amino acid pattern of 38 patients suffering from a variety of neurological conditions are reported.
ISSN:	0022-3042 1471-4159
DOI:	10.1111/j.1471-4159.1970.tb02193.x