Effect of bilirubin infusion on excretion of bilirubin and biliverdin in rabbits

1. 1. Intravenous infusion of bilirubin (BR) at 171 μg/min/kg into rabbits resulted in biliary concentration of BR increasing from 3.8 (control) to 243 mg/dl and BR excretion increasing from 1.7 to 66 μg/min/kg. 2. 2. BR infusion resulted in biliary concentrations of biliverdin (BV) increasing from...

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Veröffentlicht in:	Comparative biochemistry and physiology. A, Comparative physiology Comparative physiology, 1983, Vol.76 (2), p.339-344
Hauptverfasser:	Bruss, Michael L, Cornelius, Charles E, Himes, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bilirubin - administration & dosage Bilirubin - analogs & derivatives Bilirubin - pharmacology Bilirubin - urine Biliverdine - urine Biological and medical sciences Fundamental and applied biological sciences. Psychology Infusions, Parenteral Liver. Bile. Biliary tracts Male Rabbits Vertebrates: digestive system
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Zusammenfassung:	1. 1. Intravenous infusion of bilirubin (BR) at 171 μg/min/kg into rabbits resulted in biliary concentration of BR increasing from 3.8 (control) to 243 mg/dl and BR excretion increasing from 1.7 to 66 μg/min/kg. 2. 2. BR infusion resulted in biliary concentrations of biliverdin (BV) increasing from 9.1 to 30 g/dl and BV excretion increasing from 4.2 to 8.2 μg/min/kg. 3. 3. BR infusion produced a progressive decline in bile flow. 4. 4. BV was the predominant bile pigment in control rabbits fed either an alfalfa-based or chlorophyll-free diet. 5. 5. These results imply that rabbits can oxidize BR to BV.
ISSN:	0300-9629
DOI:	10.1016/0300-9629(83)90335-3