Contractile responses of uterine smooth muscle to acetylcholine and marihuana extract

Marihuana extract (ME) is known to influence smooth muscle activity. This study was designed to investigate the effect of crude ME on rat uterine muscle and to explain the mechanism of action using antagonists such as atropine, ergometrine and propranolol. The contractions and the electrical activit...

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Veröffentlicht in:	International journal of gynecology and obstetrics 1983-06, Vol.21 (3), p.223-226
Hauptverfasser:	Murthy, N.V.A., Melville, G.N., Wynter, Hugh H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine - pharmacology Animals Atropine - pharmacology Biological and medical sciences Cannabis Drug addictions Ergonovine - pharmacology Estrus Female Implication to fetus Marihuana extract Mechanism of action Medical sciences Muscle, Smooth - drug effects Oxygen/nutrient transfer Placental oxygen transfer Plant Extracts - pharmacology Pregnancy Propranolol - pharmacology Rats Smooth muscle activity Toxicology Uterine Contraction - drug effects
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Beschreibung
Zusammenfassung:	Marihuana extract (ME) is known to influence smooth muscle activity. This study was designed to investigate the effect of crude ME on rat uterine muscle and to explain the mechanism of action using antagonists such as atropine, ergometrine and propranolol. The contractions and the electrical activity were recorded on isolated superfused rat uteri. It is speculated that ME by its uterine stimulatory action compromise uterine blood and may affect oxygen/nutrient transfer. The implication of this to the fetus is discussed.
ISSN:	0020-7292 1879-3479
DOI:	10.1016/0020-7292(83)90084-X