Sleep Deprivation Decreases Ventilatory Response to CO2 But Not Load Compensation
Because sleep is known to reduce ventilatory drive, and sleep deprivation is a common accompaniment to ventilatory failure, we tested ventilatory response to carbon dioxide (ΔV1/ΔPco2) and response to an inspiratory flow resistive load (change in ΔP100/ΔPco2 with load) after both a normal night of s...
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| Veröffentlicht in: | Chest 1983-12, Vol.84 (6), p.695-698 |
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| container_end_page | 698 |
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| container_issue | 6 |
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| container_title | Chest |
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| creator | Schiffman, Philip L. Trontell, Marie C. Mazar, Martin F. Edelman, Norman H. |
| description | Because sleep is known to reduce ventilatory drive, and sleep deprivation is a common accompaniment to ventilatory failure, we tested ventilatory response to carbon dioxide (ΔV1/ΔPco2) and response to an inspiratory flow resistive load (change in ΔP100/ΔPco2 with load) after both a normal night of sleep and after 24 hours of sleep deprivation in 13 healthy volunteers. Sleep deprivation was associated with a significant decrease in ΔV1/ΔPco2 from 2.51 ±.36 to 2.09 ±.34 L/min/mm Hg (p |
| doi_str_mv | 10.1378/chest.84.6.695 |
| format | Article |
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Sleep deprivation was associated with a significant decrease in ΔV1/ΔPco2 from 2.51 ±.36 to 2.09 ±.34 L/min/mm Hg (p<0.02). However, load compensation was preserved during sleep deprivation. Since many acutely-ill patients are sleep deprived, an associated reduction of ventilatory drive may play a role in progressive respiratory insufficiency.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.84.6.695</identifier><identifier>PMID: 6416752</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Adult ; Air breathing ; Biological and medical sciences ; Carbon Dioxide - pharmacology ; Female ; Forced Expiratory Volume ; Fundamental and applied biological sciences. 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Sleep deprivation was associated with a significant decrease in ΔV1/ΔPco2 from 2.51 ±.36 to 2.09 ±.34 L/min/mm Hg (p<0.02). However, load compensation was preserved during sleep deprivation. Since many acutely-ill patients are sleep deprived, an associated reduction of ventilatory drive may play a role in progressive respiratory insufficiency.</description><subject>Adult</subject><subject>Air breathing</subject><subject>Biological and medical sciences</subject><subject>Carbon Dioxide - pharmacology</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Partial Pressure</subject><subject>Pulmonary Ventilation</subject><subject>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</subject><subject>Sleep Deprivation - physiology</subject><subject>Space life sciences</subject><subject>Spirometry</subject><subject>Vertebrates: respiratory system</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEmPFCEYhonRjO3o1ZtJHYy3KlkKKI7arknHieuV0NSHzYQqaoAaM_9enO6MXjyxfO8CD0JPCe4Ik8NLe4BcuqHvRCcUv4c2RDHSMt6z-2iDMaEtE4o-RI9yvsT1TJQ4Q2eiJ0JyukGfvwaApXkDS_LXpvg4171NYDLk5gfMxQdTYrppvkBe4pyhKbHZXtDm9VqaT7E0u2jGZhunBeZ863-MHjgTMjw5refo-7u337Yf2t3F-4_bV7vW9liWVhisRmesBUaUlU7SXgo8jCPeU0UGQagwhjoMoMzejU5IWe-4sm5PheCOnaMXx9wlxau1QtCTzxZCMDPENesBS04U51XYHYU2xZwTOF3_Opl0ownWfxjqW4Z66LXQlWE1PDslr_sJxjv5CVqdPz_NTbYmuGRm6_OdTAnOMBV_ew_-5-GXT6DzZEKooezYeBnXNJvwT-9wNEDFdu0h6Ww9zBbGarZFj9H_78m_AWdinvU</recordid><startdate>198312</startdate><enddate>198312</enddate><creator>Schiffman, Philip L.</creator><creator>Trontell, Marie C.</creator><creator>Mazar, Martin F.</creator><creator>Edelman, Norman H.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198312</creationdate><title>Sleep Deprivation Decreases Ventilatory Response to CO2 But Not Load Compensation</title><author>Schiffman, Philip L. ; Trontell, Marie C. ; Mazar, Martin F. ; Edelman, Norman H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-6a09dfacce319c7f7247608dd0b29186126aa2f0ee9abfdf67761259cfb2665f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Air breathing</topic><topic>Biological and medical sciences</topic><topic>Carbon Dioxide - pharmacology</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Partial Pressure</topic><topic>Pulmonary Ventilation</topic><topic>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</topic><topic>Sleep Deprivation - physiology</topic><topic>Space life sciences</topic><topic>Spirometry</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schiffman, Philip L.</creatorcontrib><creatorcontrib>Trontell, Marie C.</creatorcontrib><creatorcontrib>Mazar, Martin F.</creatorcontrib><creatorcontrib>Edelman, Norman H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schiffman, Philip L.</au><au>Trontell, Marie C.</au><au>Mazar, Martin F.</au><au>Edelman, Norman H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sleep Deprivation Decreases Ventilatory Response to CO2 But Not Load Compensation</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1983-12</date><risdate>1983</risdate><volume>84</volume><issue>6</issue><spage>695</spage><epage>698</epage><pages>695-698</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Because sleep is known to reduce ventilatory drive, and sleep deprivation is a common accompaniment to ventilatory failure, we tested ventilatory response to carbon dioxide (ΔV1/ΔPco2) and response to an inspiratory flow resistive load (change in ΔP100/ΔPco2 with load) after both a normal night of sleep and after 24 hours of sleep deprivation in 13 healthy volunteers. Sleep deprivation was associated with a significant decrease in ΔV1/ΔPco2 from 2.51 ±.36 to 2.09 ±.34 L/min/mm Hg (p<0.02). However, load compensation was preserved during sleep deprivation. Since many acutely-ill patients are sleep deprived, an associated reduction of ventilatory drive may play a role in progressive respiratory insufficiency.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>6416752</pmid><doi>10.1378/chest.84.6.695</doi><tpages>4</tpages></addata></record> |
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| ispartof | Chest, 1983-12, Vol.84 (6), p.695-698 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Air breathing Biological and medical sciences Carbon Dioxide - pharmacology Female Forced Expiratory Volume Fundamental and applied biological sciences. Psychology Humans Male Partial Pressure Pulmonary Ventilation Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Sleep Deprivation - physiology Space life sciences Spirometry Vertebrates: respiratory system |
| title | Sleep Deprivation Decreases Ventilatory Response to CO2 But Not Load Compensation |
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