Sleep Deprivation Decreases Ventilatory Response to CO2 But Not Load Compensation

Because sleep is known to reduce ventilatory drive, and sleep deprivation is a common accompaniment to ventilatory failure, we tested ventilatory response to carbon dioxide (ΔV1/ΔPco2) and response to an inspiratory flow resistive load (change in ΔP100/ΔPco2 with load) after both a normal night of s...

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Veröffentlicht in:	Chest 1983-12, Vol.84 (6), p.695-698
Hauptverfasser:	Schiffman, Philip L., Trontell, Marie C., Mazar, Martin F., Edelman, Norman H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Air breathing Biological and medical sciences Carbon Dioxide - pharmacology Female Forced Expiratory Volume Fundamental and applied biological sciences. Psychology Humans Male Partial Pressure Pulmonary Ventilation Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Sleep Deprivation - physiology Space life sciences Spirometry Vertebrates: respiratory system
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Zusammenfassung:	Because sleep is known to reduce ventilatory drive, and sleep deprivation is a common accompaniment to ventilatory failure, we tested ventilatory response to carbon dioxide (ΔV1/ΔPco2) and response to an inspiratory flow resistive load (change in ΔP100/ΔPco2 with load) after both a normal night of sleep and after 24 hours of sleep deprivation in 13 healthy volunteers. Sleep deprivation was associated with a significant decrease in ΔV1/ΔPco2 from 2.51 ±.36 to 2.09 ±.34 L/min/mm Hg (p
ISSN:	0012-3692 1931-3543
DOI:	10.1378/chest.84.6.695