Release of γ-aminobutyric acid from guinea pig myenteric plexus synaptosomes

A crude synaptosomal preparation obtained from myenteric plexus of guinea pig small intestine was used to study the release of [ 3H]GABA. GABA release was elevated in response to depolarizing agents when tested in normal Krebs but was depressed in a calcium-free medium. GABA was also noted to stimul...

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Veröffentlicht in:	Brain research 1983-11, Vol.278 (1), p.271-273
Hauptverfasser:	Yau, William M., Verdun, Pamela R.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Acetylcholine - metabolism Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology GABA gamma -aminobutyric acid gamma-Aminobutyric Acid - metabolism gamma-Aminobutyric Acid - pharmacology Guinea Pigs Intestine. Mesentery L-Lactate Dehydrogenase - metabolism myenteric plexus Myenteric Plexus - metabolism Myenteric Plexus - ultrastructure nerve transmission release small intestine Synapses - metabolism synaptosome synaptosomes Synaptosomes - enzymology Synaptosomes - metabolism Vertebrates: digestive system
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Zusammenfassung:	A crude synaptosomal preparation obtained from myenteric plexus of guinea pig small intestine was used to study the release of [ 3H]GABA. GABA release was elevated in response to depolarizing agents when tested in normal Krebs but was depressed in a calcium-free medium. GABA was also noted to stimulate a release of [ 3H]ACh from the same preparation. These data support the possible role of GABA as an enteric neurotransmitter.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(83)90252-4