Chloroquine resistant Plasmodium falciparum on the island of Flores, Indonesia

Chloroquine resistant Plasmodium falciparum on the island of Flores, Indonesia

The in vitro sensitivity of Plasmodium falciparum to chloroquine was studied in parasites from 45 children on the island of Flores, Indonesia. The micro in vitro culture technique and a 12-volt battery-operated field incubator were found to be well suited to the field situation encountered. Parasite...

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Veröffentlicht in:Transactions of the Royal Society of Tropical Medicine and Hygiene 1983, Vol.77 (4), p.459-462
Hauptverfasser: Smrkovski, Lloyd L., Hoffman, Stephen L., Purnomo, Hussein, R.P., Masbar, Sofyan, Kurniawan, Llliana
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Animals
Child
Child, Preschool
Chloroquine - pharmacology
Drug Resistance, Microbial
Female
Humans
Indonesia
Infant
malaria
Malaria - parasitology
Male
Microbial Sensitivity Tests
Plasmodium falciparum
Plasmodium falciparum - drug effects
Resistance, Drug
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Zusammenfassung:The in vitro sensitivity of Plasmodium falciparum to chloroquine was studied in parasites from 45 children on the island of Flores, Indonesia. The micro in vitro culture technique and a 12-volt battery-operated field incubator were found to be well suited to the field situation encountered. Parasites from seven children (15·6%) were resistant to chloroquine in vitro: two at 8 pico-moles of chloroquine, two at 16 pico-moles, and three at 32 pico-moles. This is the first report of chloroquine resistant from Flores.
ISSN:0035-9203
1878-3503
DOI:10.1016/0035-9203(83)90112-8