Tacrolimus-induced polyneuropathy after heart transplantation

Tacrolimus has been often described to induce neuropathy in liver-, pancreas-, and renal-transplanted patients. Here, we report the first case of a 56-year-old woman who developed a progressive symmetric demyelinating sensorimotor polyneuropathy in the distal muscles of the lower limbs after therapy...

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Veröffentlicht in:	Clinical neuropharmacology 2010-05, Vol.33 (3), p.161-162
Hauptverfasser:	Labate, Angelo, Morelli, Maurizio, Palamara, Grazia, Pirritano, Domenico, Quattrone, Aldo
Format:	Artikel
Sprache:	eng
Schlagworte:	Demyelinating Diseases - chemically induced Demyelinating Diseases - complications Demyelinating Diseases - diagnosis Diagnosis, Differential Disease Progression Drug Monitoring Female Heart Transplantation Humans Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Lower Extremity Middle Aged Polyneuropathies - chemically induced Polyneuropathies - complications Polyneuropathies - diagnosis Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - diagnosis Tacrolimus - adverse effects Tacrolimus - therapeutic use Treatment Outcome
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Zusammenfassung:	Tacrolimus has been often described to induce neuropathy in liver-, pancreas-, and renal-transplanted patients. Here, we report the first case of a 56-year-old woman who developed a progressive symmetric demyelinating sensorimotor polyneuropathy in the distal muscles of the lower limbs after therapy with tacrolimus because of heart transplantation. This condition suddenly reverted after the tacrolimus was stopped.
ISSN:	0362-5664 1537-162X
DOI:	10.1097/WNF.0b013e3181dc4f43