Can autism be triggered by acetaminophen activation of the endocannabinoid system?
Acetaminophen use in children has been associated with increased autism risk. Recent evidence suggests that acetaminophen's analgesic actions result from activation of the endocannabinoid system, and activation of this system can have neuromodulatory consequences during development. This invest...
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Veröffentlicht in: | Acta neurobiologiae experimentalis 2010-01, Vol.70 (2), p.227-231 |
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description | Acetaminophen use in children has been associated with increased autism risk. Recent evidence suggests that acetaminophen's analgesic actions result from activation of the endocannabinoid system, and activation of this system can have neuromodulatory consequences during development. This investigation was performed to determine if there is evidence to support the hypothesis that acetaminophen use can trigger autism by activation of the endocannabinoid system. |
doi_str_mv | 10.55782/ane-2010-1793 |
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Recent evidence suggests that acetaminophen's analgesic actions result from activation of the endocannabinoid system, and activation of this system can have neuromodulatory consequences during development. 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Recent evidence suggests that acetaminophen's analgesic actions result from activation of the endocannabinoid system, and activation of this system can have neuromodulatory consequences during development. This investigation was performed to determine if there is evidence to support the hypothesis that acetaminophen use can trigger autism by activation of the endocannabinoid system.</description><subject>Acetaminophen - adverse effects</subject><subject>Acetaminophen - metabolism</subject><subject>Acetaminophen - therapeutic use</subject><subject>Autistic Disorder - chemically induced</subject><subject>Cannabinoid Receptor Modulators - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Endocannabinoids</subject><subject>Fever - drug therapy</subject><subject>Humans</subject><subject>Monocytes - drug effects</subject><subject>Receptor, Cannabinoid, CB1 - metabolism</subject><subject>Receptor, Cannabinoid, CB2 - metabolism</subject><issn>0065-1400</issn><issn>1689-0035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PwzAURS0EoqWwMiJvTCnPTmwnE0IVX1IlJASz5dgvrVGTlNhB6r_HpcB0l3Ov3juEXDKYC6FKfmM6zDgwyJiq8iMyZbKsMoBcHJMpgBQZKwAm5CyEDwCuFIdTMuEgeVkUYkpeF6ajZow-tLRGGge_WuGAjtY7aixG0_qu364xQTb6LxN939G-oXGNFDvXW9N1pk6MdzTsQsT29pycNGYT8OI3Z-T94f5t8ZQtXx6fF3fLzOaCxUyIykmrbAXSGgRecOuUQVFWUhVKVulaV6ewoHKHDZTGMudqi6YooZYin5Hrw-526D9HDFG3PljcbJKSfgy6BJWe5Ioncn4g7dCHMGCjt4NvzbDTDPSPRp06eq9R7zWmwtXv9Fi36P7xP2_5N2YUbnQ</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Schultz, Stephen T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20100101</creationdate><title>Can autism be triggered by acetaminophen activation of the endocannabinoid system?</title><author>Schultz, Stephen T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-559d6c7c906cae0242cd7ae589674769002db690c073def08ac1ddbcea480b653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acetaminophen - adverse effects</topic><topic>Acetaminophen - metabolism</topic><topic>Acetaminophen - therapeutic use</topic><topic>Autistic Disorder - chemically induced</topic><topic>Cannabinoid Receptor Modulators - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Endocannabinoids</topic><topic>Fever - drug therapy</topic><topic>Humans</topic><topic>Monocytes - drug effects</topic><topic>Receptor, Cannabinoid, CB1 - metabolism</topic><topic>Receptor, Cannabinoid, CB2 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schultz, Stephen T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Acta neurobiologiae experimentalis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schultz, Stephen T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can autism be triggered by acetaminophen activation of the endocannabinoid system?</atitle><jtitle>Acta neurobiologiae experimentalis</jtitle><addtitle>Acta Neurobiol Exp (Wars)</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>70</volume><issue>2</issue><spage>227</spage><epage>231</epage><pages>227-231</pages><issn>0065-1400</issn><eissn>1689-0035</eissn><abstract>Acetaminophen use in children has been associated with increased autism risk. 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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
subjects | Acetaminophen - adverse effects Acetaminophen - metabolism Acetaminophen - therapeutic use Autistic Disorder - chemically induced Cannabinoid Receptor Modulators - metabolism Child Child, Preschool Endocannabinoids Fever - drug therapy Humans Monocytes - drug effects Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB2 - metabolism |
title | Can autism be triggered by acetaminophen activation of the endocannabinoid system? |
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