Can autism be triggered by acetaminophen activation of the endocannabinoid system?

Acetaminophen use in children has been associated with increased autism risk. Recent evidence suggests that acetaminophen's analgesic actions result from activation of the endocannabinoid system, and activation of this system can have neuromodulatory consequences during development. This invest...

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Veröffentlicht in:Acta neurobiologiae experimentalis 2010-01, Vol.70 (2), p.227-231
1. Verfasser: Schultz, Stephen T
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creator Schultz, Stephen T
description Acetaminophen use in children has been associated with increased autism risk. Recent evidence suggests that acetaminophen's analgesic actions result from activation of the endocannabinoid system, and activation of this system can have neuromodulatory consequences during development. This investigation was performed to determine if there is evidence to support the hypothesis that acetaminophen use can trigger autism by activation of the endocannabinoid system.
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subjects Acetaminophen - adverse effects
Acetaminophen - metabolism
Acetaminophen - therapeutic use
Autistic Disorder - chemically induced
Cannabinoid Receptor Modulators - metabolism
Child
Child, Preschool
Endocannabinoids
Fever - drug therapy
Humans
Monocytes - drug effects
Receptor, Cannabinoid, CB1 - metabolism
Receptor, Cannabinoid, CB2 - metabolism
title Can autism be triggered by acetaminophen activation of the endocannabinoid system?
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