Can autism be triggered by acetaminophen activation of the endocannabinoid system?

Acetaminophen use in children has been associated with increased autism risk. Recent evidence suggests that acetaminophen's analgesic actions result from activation of the endocannabinoid system, and activation of this system can have neuromodulatory consequences during development. This invest...

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Veröffentlicht in:	Acta neurobiologiae experimentalis 2010-01, Vol.70 (2), p.227-231
1. Verfasser:	Schultz, Stephen T
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - adverse effects Acetaminophen - metabolism Acetaminophen - therapeutic use Autistic Disorder - chemically induced Cannabinoid Receptor Modulators - metabolism Child Child, Preschool Endocannabinoids Fever - drug therapy Humans Monocytes - drug effects Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB2 - metabolism
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Zusammenfassung:	Acetaminophen use in children has been associated with increased autism risk. Recent evidence suggests that acetaminophen's analgesic actions result from activation of the endocannabinoid system, and activation of this system can have neuromodulatory consequences during development. This investigation was performed to determine if there is evidence to support the hypothesis that acetaminophen use can trigger autism by activation of the endocannabinoid system.
ISSN:	0065-1400 1689-0035
DOI:	10.55782/ane-2010-1793