Elevated Level of Soluble Interleukin-2 Receptor in Bronchoalveolar Lavage Fluid from Sarcoidosis Patients
Pulmonary sarcoidosis is a granulomatous disorder of unknown cause, characterized by an accumulation of active T lymphocytes in the lung. We measured the levels of soluble interleukin-2 receptor (IL-2R) in bronchoalveolar lavage fluid (BALF) of patients with active pulmonary sarcoidosis and normal s...
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| Veröffentlicht in: | Japanese Journal of Medicine 1991, Vol.30(2), pp.113-117 |
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| container_title | Japanese Journal of Medicine |
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| creator | OGUSHI, Fumitaka SONE, Saburo SINGH, Sukh M. TANI, Kenji OZAKI, Toshio YASUOKA, Susumu OGURA, Takeshi HONDA, Mituo |
| description | Pulmonary sarcoidosis is a granulomatous disorder of unknown cause, characterized by an accumulation of active T lymphocytes in the lung. We measured the levels of soluble interleukin-2 receptor (IL-2R) in bronchoalveolar lavage fluid (BALF) of patients with active pulmonary sarcoidosis and normal subjects by a sensitive enzyme-linked immunosorbent assay. Soluble IL-2R was detectable in BALF from 6 of 11 patients with sarcoidosis but in only 1 of 8 normal control subjects, the mean levels of IL-2R in BALF of the two groups being 2.8±0.9 U/ml and 0.1±0.1 U/ml, respectively (p |
| doi_str_mv | 10.2169/internalmedicine1962.30.113 |
| format | Article |
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We measured the levels of soluble interleukin-2 receptor (IL-2R) in bronchoalveolar lavage fluid (BALF) of patients with active pulmonary sarcoidosis and normal subjects by a sensitive enzyme-linked immunosorbent assay. Soluble IL-2R was detectable in BALF from 6 of 11 patients with sarcoidosis but in only 1 of 8 normal control subjects, the mean levels of IL-2R in BALF of the two groups being 2.8±0.9 U/ml and 0.1±0.1 U/ml, respectively (p<0.01). A slight correlation was found between the soluble IL-2R level and the number of CD4-positive cells. Sarcoidosis patients were classified by radiographical staging. Soluble IL-2R was not detectable in the BALF of any stage I patients, but was found in the BALF of 6 of the 7 stage II and stage III patients. These results suggest that in the clinical management of patients with sarcoidosis, measurement of soluble IL-2R in BALF is useful for evaluating the activity of the lung disease is sarcoidosis.</description><identifier>ISSN: 0021-5120</identifier><identifier>EISSN: 1881-123X</identifier><identifier>DOI: 10.2169/internalmedicine1962.30.113</identifier><identifier>PMID: 1678021</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Adult ; Bronchoalveolar Lavage Fluid - chemistry ; Bronchoalveolar Lavage Fluid - pathology ; CD4-Positive T-Lymphocytes ; Department of Cellular Immunology, National Institute of Health ; Disease activity in sarcoidosis ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Leukocyte Count ; Lung Diseases - metabolism ; Lung Diseases - pathology ; Lymphocyte subsets ; Male ; Middle Aged ; Receptors, Interleukin-2 - analysis ; Sarcoidosis - metabolism ; Sarcoidosis - pathology ; Smoking</subject><ispartof>Japanese Journal of Medicine, 1991, Vol.30(2), pp.113-117</ispartof><rights>The Japanese Society of Internal Medicine</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-c5f4c1c941899b2dce09c9878ff73c0c78a44d44822824ef7d11f38af46b94863</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1678021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OGUSHI, Fumitaka</creatorcontrib><creatorcontrib>SONE, Saburo</creatorcontrib><creatorcontrib>SINGH, Sukh M.</creatorcontrib><creatorcontrib>TANI, Kenji</creatorcontrib><creatorcontrib>OZAKI, Toshio</creatorcontrib><creatorcontrib>YASUOKA, Susumu</creatorcontrib><creatorcontrib>OGURA, Takeshi</creatorcontrib><creatorcontrib>HONDA, Mituo</creatorcontrib><title>Elevated Level of Soluble Interleukin-2 Receptor in Bronchoalveolar Lavage Fluid from Sarcoidosis Patients</title><title>Japanese Journal of Medicine</title><addtitle>Japanese Journal of Medicine</addtitle><description>Pulmonary sarcoidosis is a granulomatous disorder of unknown cause, characterized by an accumulation of active T lymphocytes in the lung. We measured the levels of soluble interleukin-2 receptor (IL-2R) in bronchoalveolar lavage fluid (BALF) of patients with active pulmonary sarcoidosis and normal subjects by a sensitive enzyme-linked immunosorbent assay. Soluble IL-2R was detectable in BALF from 6 of 11 patients with sarcoidosis but in only 1 of 8 normal control subjects, the mean levels of IL-2R in BALF of the two groups being 2.8±0.9 U/ml and 0.1±0.1 U/ml, respectively (p<0.01). A slight correlation was found between the soluble IL-2R level and the number of CD4-positive cells. Sarcoidosis patients were classified by radiographical staging. Soluble IL-2R was not detectable in the BALF of any stage I patients, but was found in the BALF of 6 of the 7 stage II and stage III patients. These results suggest that in the clinical management of patients with sarcoidosis, measurement of soluble IL-2R in BALF is useful for evaluating the activity of the lung disease is sarcoidosis.</description><subject>Adult</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Bronchoalveolar Lavage Fluid - pathology</subject><subject>CD4-Positive T-Lymphocytes</subject><subject>Department of Cellular Immunology, National Institute of Health</subject><subject>Disease activity in sarcoidosis</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Lung Diseases - metabolism</subject><subject>Lung Diseases - pathology</subject><subject>Lymphocyte subsets</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Receptors, Interleukin-2 - analysis</subject><subject>Sarcoidosis - metabolism</subject><subject>Sarcoidosis - pathology</subject><subject>Smoking</subject><issn>0021-5120</issn><issn>1881-123X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1qGzEURkVoSdw0jxAQFLobV3-e0dBVE-I2YIhpGshOyJqrRI4sOZLGkLevgk26aTZXi_Pd-6GD0BdKpoy2_TcXCqSg_QYGZ1wA2rdsysmUUn6EJlRK2lDG7z-gCSGMNjPKyAn6lPOaENEyyY7RMW07WdkEra887HSBAS9gBx5Hi2-jH1ce8PVrjYfxyYWG4d9gYFtiwi7gixSDeYza7yB6nfBC7_QD4Lkf3YBtiht8q5OJbojZZbzUxUEo-TP6aLXPcHZ4T9Hd_OrP5a9mcfPz-vLHojGzdlbqtMJQ0wsq-37FBgOkN73spLUdN8R0UgsxCCFZ_YoA2w2UWi61Fe2qF7Llp-jr_u42xecRclEblw14rwPEMStJOta1vKvB7_ugSTHnBFZtk9vo9KIoUa-m1f9MK05UNV23zw8146ryf7t7tZUv93ydS7XzxnUqznh49_Zh1Iq3qHnUSUHgfwESAJ32</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>OGUSHI, Fumitaka</creator><creator>SONE, Saburo</creator><creator>SINGH, Sukh M.</creator><creator>TANI, Kenji</creator><creator>OZAKI, Toshio</creator><creator>YASUOKA, Susumu</creator><creator>OGURA, Takeshi</creator><creator>HONDA, Mituo</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Elevated Level of Soluble Interleukin-2 Receptor in Bronchoalveolar Lavage Fluid from Sarcoidosis Patients</title><author>OGUSHI, Fumitaka ; SONE, Saburo ; SINGH, Sukh M. ; TANI, Kenji ; OZAKI, Toshio ; YASUOKA, Susumu ; OGURA, Takeshi ; HONDA, Mituo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-c5f4c1c941899b2dce09c9878ff73c0c78a44d44822824ef7d11f38af46b94863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Bronchoalveolar Lavage Fluid - chemistry</topic><topic>Bronchoalveolar Lavage Fluid - pathology</topic><topic>CD4-Positive T-Lymphocytes</topic><topic>Department of Cellular Immunology, National Institute of Health</topic><topic>Disease activity in sarcoidosis</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Lung Diseases - metabolism</topic><topic>Lung Diseases - pathology</topic><topic>Lymphocyte subsets</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Receptors, Interleukin-2 - analysis</topic><topic>Sarcoidosis - metabolism</topic><topic>Sarcoidosis - pathology</topic><topic>Smoking</topic><toplevel>online_resources</toplevel><creatorcontrib>OGUSHI, Fumitaka</creatorcontrib><creatorcontrib>SONE, Saburo</creatorcontrib><creatorcontrib>SINGH, Sukh M.</creatorcontrib><creatorcontrib>TANI, Kenji</creatorcontrib><creatorcontrib>OZAKI, Toshio</creatorcontrib><creatorcontrib>YASUOKA, Susumu</creatorcontrib><creatorcontrib>OGURA, Takeshi</creatorcontrib><creatorcontrib>HONDA, Mituo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Journal of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OGUSHI, Fumitaka</au><au>SONE, Saburo</au><au>SINGH, Sukh M.</au><au>TANI, Kenji</au><au>OZAKI, Toshio</au><au>YASUOKA, Susumu</au><au>OGURA, Takeshi</au><au>HONDA, Mituo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated Level of Soluble Interleukin-2 Receptor in Bronchoalveolar Lavage Fluid from Sarcoidosis Patients</atitle><jtitle>Japanese Journal of Medicine</jtitle><addtitle>Japanese Journal of Medicine</addtitle><date>1991</date><risdate>1991</risdate><volume>30</volume><issue>2</issue><spage>113</spage><epage>117</epage><pages>113-117</pages><issn>0021-5120</issn><eissn>1881-123X</eissn><abstract>Pulmonary sarcoidosis is a granulomatous disorder of unknown cause, characterized by an accumulation of active T lymphocytes in the lung. We measured the levels of soluble interleukin-2 receptor (IL-2R) in bronchoalveolar lavage fluid (BALF) of patients with active pulmonary sarcoidosis and normal subjects by a sensitive enzyme-linked immunosorbent assay. Soluble IL-2R was detectable in BALF from 6 of 11 patients with sarcoidosis but in only 1 of 8 normal control subjects, the mean levels of IL-2R in BALF of the two groups being 2.8±0.9 U/ml and 0.1±0.1 U/ml, respectively (p<0.01). A slight correlation was found between the soluble IL-2R level and the number of CD4-positive cells. Sarcoidosis patients were classified by radiographical staging. Soluble IL-2R was not detectable in the BALF of any stage I patients, but was found in the BALF of 6 of the 7 stage II and stage III patients. These results suggest that in the clinical management of patients with sarcoidosis, measurement of soluble IL-2R in BALF is useful for evaluating the activity of the lung disease is sarcoidosis.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>1678021</pmid><doi>10.2169/internalmedicine1962.30.113</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Japanese Journal of Medicine, 1991, Vol.30(2), pp.113-117 |
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| subjects | Adult Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - pathology CD4-Positive T-Lymphocytes Department of Cellular Immunology, National Institute of Health Disease activity in sarcoidosis Enzyme-Linked Immunosorbent Assay Female Humans Leukocyte Count Lung Diseases - metabolism Lung Diseases - pathology Lymphocyte subsets Male Middle Aged Receptors, Interleukin-2 - analysis Sarcoidosis - metabolism Sarcoidosis - pathology Smoking |
| title | Elevated Level of Soluble Interleukin-2 Receptor in Bronchoalveolar Lavage Fluid from Sarcoidosis Patients |
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