Elevated Level of Soluble Interleukin-2 Receptor in Bronchoalveolar Lavage Fluid from Sarcoidosis Patients

Pulmonary sarcoidosis is a granulomatous disorder of unknown cause, characterized by an accumulation of active T lymphocytes in the lung. We measured the levels of soluble interleukin-2 receptor (IL-2R) in bronchoalveolar lavage fluid (BALF) of patients with active pulmonary sarcoidosis and normal s...

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Veröffentlicht in:	Japanese Journal of Medicine 1991, Vol.30(2), pp.113-117
Hauptverfasser:	OGUSHI, Fumitaka, SONE, Saburo, SINGH, Sukh M., TANI, Kenji, OZAKI, Toshio, YASUOKA, Susumu, OGURA, Takeshi, HONDA, Mituo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - pathology CD4-Positive T-Lymphocytes Department of Cellular Immunology, National Institute of Health Disease activity in sarcoidosis Enzyme-Linked Immunosorbent Assay Female Humans Leukocyte Count Lung Diseases - metabolism Lung Diseases - pathology Lymphocyte subsets Male Middle Aged Receptors, Interleukin-2 - analysis Sarcoidosis - metabolism Sarcoidosis - pathology Smoking
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Zusammenfassung:	Pulmonary sarcoidosis is a granulomatous disorder of unknown cause, characterized by an accumulation of active T lymphocytes in the lung. We measured the levels of soluble interleukin-2 receptor (IL-2R) in bronchoalveolar lavage fluid (BALF) of patients with active pulmonary sarcoidosis and normal subjects by a sensitive enzyme-linked immunosorbent assay. Soluble IL-2R was detectable in BALF from 6 of 11 patients with sarcoidosis but in only 1 of 8 normal control subjects, the mean levels of IL-2R in BALF of the two groups being 2.8±0.9 U/ml and 0.1±0.1 U/ml, respectively (p
ISSN:	0021-5120 1881-123X
DOI:	10.2169/internalmedicine1962.30.113