Multigenic control of Listeria monocytogenes susceptibility in mice

We have used a novel quantitative trait locus model to study the genetics of survival of F2 progeny of susceptible BALB/cByJ and resistant C57BL/6ByJ mice that have been infected with Listeria monocytogenes. This allowed us to map modifiers of L. monocytogenes susceptibility to chromosomes 5 and 13.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2001-03, Vol.27 (3), p.259-260
Hauptverfasser:	Dietrich, William F, Boyartchuk, Victor L, Broman, Karl W, Mosher, Rebecca E, D'Orazio, Sarah E.F, Starnbach, Michael N
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscesses Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Chromatin. Chromosome chromosome 13 chromosome 5 Chromosome Mapping Chromosomes Crosses, Genetic Diagnosis Female Fundamental and applied biological sciences. Psychology Gene expression Gene Function Gene mapping Genetic aspects Genetics Granulomas Health aspects Human Genetics Infections Listeria Listeria monocytogenes Listeriosis Listeriosis - genetics Listeriosis - immunology Listeriosis - pathology Liver Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Molecular and cellular biology Molecular genetics Neutrophils Publishing Quantitative Trait, Heritable Risk factors
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Beschreibung
Zusammenfassung:	We have used a novel quantitative trait locus model to study the genetics of survival of F2 progeny of susceptible BALB/cByJ and resistant C57BL/6ByJ mice that have been infected with Listeria monocytogenes. This allowed us to map modifiers of L. monocytogenes susceptibility to chromosomes 5 and 13.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/85812