Caught in the Act: In Vivo Development of Macrolide Resistance to Campylobacter jejuni Infection

We report the first instance of macrolide resistance developing in vivo following appropriate antibiotic use in a healthy volunteer as a part of a controlled human infection with Campylobacter jejuni. In vivo development of macrolide resistance may be an important contributor to antibiotic resistanc...

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Veröffentlicht in:	Journal of Clinical Microbiology 2010-08, Vol.48 (8), p.3012-3015
Hauptverfasser:	Lindow, J.C, Poly, F, Tribble, D.R, Guerry, P, Carmolli, M.P, Baqar, S, Porter, C.K, Pierce, K.K, Darsley, M.J, Sadigh, K.S, Dill, E.A, Kirkpatrick, B.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacterial Typing Techniques Bacteriology Biological and medical sciences Campylobacter Infections - drug therapy Campylobacter Infections - microbiology Campylobacter jejuni Campylobacter jejuni - classification Campylobacter jejuni - drug effects Campylobacter jejuni - genetics Campylobacter jejuni - isolation & purification Case Reports DNA Fingerprinting DNA, Bacterial - genetics Drug Resistance, Bacterial Electrophoresis, Gel, Pulsed-Field Fundamental and applied biological sciences. Psychology Healthy Volunteers Humans Macrolides - pharmacology Macrolides - therapeutic use Male Microbial Sensitivity Tests Microbiology Miscellaneous Young Adult
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Zusammenfassung:	We report the first instance of macrolide resistance developing in vivo following appropriate antibiotic use in a healthy volunteer as a part of a controlled human infection with Campylobacter jejuni. In vivo development of macrolide resistance may be an important contributor to antibiotic resistance in C. jejuni.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.00768-10