Activity of doripenem with and without levofloxacin, amikacin, and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii

Abstract At 24 h, sub-MIC doripenem and levofloxacin showed synergy against 21 of 25 Pseudomonas aeruginosa strains, sub-MIC doripenem and amikacin against 22 isolates, and sub-MIC doripenem and colistin against 19 isolates. Of 25 Acinetobacter baumannii strains, sub-MIC doripenem and levofloxacin s...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2010-06, Vol.67 (2), p.191-197
Hauptverfasser:	Pankuch, Glenn A, Seifert, Harald, Appelbaum, Peter C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter baumannii Acinetobacter baumannii - drug effects Acinetobacter baumannii - isolation & purification Acinetobacter Infections - microbiology Anti-Bacterial Agents - pharmacology Doripenem Drug Synergism Humans Infectious Disease Internal Medicine Microbial Sensitivity Tests Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - microbiology Time–kill synergy
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Zusammenfassung:	Abstract At 24 h, sub-MIC doripenem and levofloxacin showed synergy against 21 of 25 Pseudomonas aeruginosa strains, sub-MIC doripenem and amikacin against 22 isolates, and sub-MIC doripenem and colistin against 19 isolates. Of 25 Acinetobacter baumannii strains, sub-MIC doripenem and levofloxacin showed synergy against 11 strains at 24 h, sub-MIC doripenem and amikacin against 24 strains, and sub-MIC doripenem and colistin against all isolates.
ISSN:	0732-8893 1879-0070
DOI:	10.1016/j.diagmicrobio.2010.01.004