Clinical, microbiologic, and genetic determinants of persistent methicillin-resistant Staphylococcus aureus bacteremia

Abstract Methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) often persists despite full susceptibility to vancomycin; therefore, associated factors were assessed. A retrospective cohort analysis of 222 patients with MRSAB treated with vancomycin was conducted; patients with persistent MR...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2010-07, Vol.67 (3), p.228-233
Hauptverfasser:	Neuner, Elizabeth A, Casabar, Ed, Reichley, Richard, McKinnon, Peggy S
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacteremia Bacteremia - drug therapy Bacteremia - microbiology Bacteremia - pathology Cohort Studies Female Humans Incidence Infectious Disease Internal Medicine Male Methicillin-Resistant Staphylococcus aureus - isolation & purification Microbial Sensitivity Tests Middle Aged MRSA Retrospective Studies Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcal Infections - pathology Staphylococcus aureus Vancomycin Vancomycin - pharmacokinetics Vancomycin - pharmacology Vancomycin - therapeutic use Vancomycin Resistance
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Zusammenfassung:	Abstract Methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) often persists despite full susceptibility to vancomycin; therefore, associated factors were assessed. A retrospective cohort analysis of 222 patients with MRSAB treated with vancomycin was conducted; patients with persistent MRSAB (pMRSAB) were compared to those with nonpersistent bacteremia (NPB). Incidence of pMRSAB was 9%. More patients with vancomycin MIC = 2 mg/L had pMRSAB (16%) compared to patients with vancomycin MIC
ISSN:	0732-8893 1879-0070
DOI:	10.1016/j.diagmicrobio.2010.02.026