Improved coronary thrombolysis by tissue-type plasminogen activator in the presence of BAY U 3405

The effect of BAY U 3405 (3 mg/kg i.v.) was tested on recombinant tissue-type plasminogen activator (rt-PA)-induced thrombolysis of an experimentally induced coronary thrombosis in anaesthetized dogs. BAY U 3405. given immediately before an rt-PA infusion, reduced time to reperfusion by more than 50...

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Veröffentlicht in:	European journal of pharmacology 1991-06, Vol.198 (2), p.207-210
Hauptverfasser:	Rounding, H.Paul, Fiedler, Volker B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Pressure - drug effects Blood. Blood coagulation. Reticuloendothelial system Carbazoles - metabolism Carbazoles - pharmacology Coronary Thrombosis - drug therapy Dog Dogs Female Heart Rate - drug effects Infusions, Intravenous Male Medical sciences Pharmacology. Drug treatments Plasminogen activator Recombinant Proteins - therapeutic use Sulfonamides - metabolism Sulfonamides - pharmacology Thrombolysis Thrombolytic Therapy Thromboxane antagonists Tissue Plasminogen Activator - therapeutic use
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