Improved coronary thrombolysis by tissue-type plasminogen activator in the presence of BAY U 3405

The effect of BAY U 3405 (3 mg/kg i.v.) was tested on recombinant tissue-type plasminogen activator (rt-PA)-induced thrombolysis of an experimentally induced coronary thrombosis in anaesthetized dogs. BAY U 3405. given immediately before an rt-PA infusion, reduced time to reperfusion by more than 50...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 1991-06, Vol.198 (2), p.207-210
Hauptverfasser:	Rounding, H.Paul, Fiedler, Volker B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Pressure - drug effects Blood. Blood coagulation. Reticuloendothelial system Carbazoles - metabolism Carbazoles - pharmacology Coronary Thrombosis - drug therapy Dog Dogs Female Heart Rate - drug effects Infusions, Intravenous Male Medical sciences Pharmacology. Drug treatments Plasminogen activator Recombinant Proteins - therapeutic use Sulfonamides - metabolism Sulfonamides - pharmacology Thrombolysis Thrombolytic Therapy Thromboxane antagonists Tissue Plasminogen Activator - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The effect of BAY U 3405 (3 mg/kg i.v.) was tested on recombinant tissue-type plasminogen activator (rt-PA)-induced thrombolysis of an experimentally induced coronary thrombosis in anaesthetized dogs. BAY U 3405. given immediately before an rt-PA infusion, reduced time to reperfusion by more than 50% compared with vehicle-treated controls (P < 0.01). After cessation of the rt-PA infusion, BAY U 3405 reduced the reocclusion rate compared to controls (P < 0.05). These results show that BAY U 3405 improves rt-PA-induced coronary thrombolysis in a canine model.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(91)90623-X