A NEW ANTITUMOR ANTIBIOTIC, AWAMYCIN
A new antibiotic, awamycin, was isolated from the culture broth of Streptomyces sp. No. 80-217. It appeared to belong to the quinone indicator group from results of physicochemical studies and has the empirical formula C38H49NO12S. This antibiotic possessed antibacterial and antitumor activities aga...
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| Veröffentlicht in: | Journal of antibiotics 1983, Vol.36(9), pp.1144-1149 |
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| container_end_page | 1149 |
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| container_issue | 9 |
| container_start_page | 1144 |
| container_title | Journal of antibiotics |
| container_volume | 36 |
| creator | UMEZAWA, IWAO OKA, HIROFUMI KOMIYAMA, KANKI HAGIWARA, KEIKO TOMISAKA, SHIGERU MIYANO, TETSUJI |
| description | A new antibiotic, awamycin, was isolated from the culture broth of Streptomyces sp. No. 80-217. It appeared to belong to the quinone indicator group from results of physicochemical studies and has the empirical formula C38H49NO12S. This antibiotic possessed antibacterial and antitumor activities against Gram-positive bacteria and experimental murine tumors. The antibiotic also showed direct cytotoxic activity against HeLa cells in vitro. |
| doi_str_mv | 10.7164/antibiotics.36.1144 |
| format | Article |
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No. 80-217. It appeared to belong to the quinone indicator group from results of physicochemical studies and has the empirical formula C38H49NO12S. This antibiotic possessed antibacterial and antitumor activities against Gram-positive bacteria and experimental murine tumors. The antibiotic also showed direct cytotoxic activity against HeLa cells in vitro.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.36.1144</identifier><identifier>PMID: 6688804</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Animals ; Antibiotics ; Antibiotics, Antineoplastic - isolation & purification ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; awamycin ; Biological and medical sciences ; Biotechnology ; Carcinoma - drug therapy ; Fermentation ; Fundamental and applied biological sciences. Psychology ; gram-positive bacteria ; Health. Pharmaceutical industry ; Industrial applications and implications. Economical aspects ; Male ; Medical sciences ; Mice ; Mice, Inbred ICR ; Miscellaneous. Antibiotics with multiple activities ; Pharmacology. 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Antibiot.</addtitle><description>A new antibiotic, awamycin, was isolated from the culture broth of Streptomyces sp. No. 80-217. It appeared to belong to the quinone indicator group from results of physicochemical studies and has the empirical formula C38H49NO12S. This antibiotic possessed antibacterial and antitumor activities against Gram-positive bacteria and experimental murine tumors. The antibiotic also showed direct cytotoxic activity against HeLa cells in vitro.</description><subject>Animals</subject><subject>Antibiotics</subject><subject>Antibiotics, Antineoplastic - isolation & purification</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>awamycin</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Carcinoma - drug therapy</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gram-positive bacteria</subject><subject>Health. Pharmaceutical industry</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Miscellaneous. Antibiotics with multiple activities</subject><subject>Pharmacology. Drug treatments</subject><subject>Production of active biomolecules</subject><subject>Quinones - isolation & purification</subject><subject>Quinones - therapeutic use</subject><subject>Sarcoma 180 - drug therapy</subject><subject>Streptomyces</subject><subject>Streptomyces - growth & development</subject><subject>Streptomyces - ultrastructure</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAYhYMoc05_gQi7GF7ZmSxZPi5rmVrYB0jH8CqkaaIdXTeb7sJ_b7uWsjtvksB5znveHADuERwzRMmzyss0Tvdlqt0Y0zFChFyAPuIceYhQcQn6EE6Qx_kEXoMb57YQYoYZ74EepZxzSPpg5A-Xs83QX0ZhtF6sPk6vl3AVhcHT0N_4i88gXN6CK6syZ-7aewDWr7MoePfmq7cw8OeennJEPBNbQbhKmE64pVjEMSTKTARhnFhjiRWCodhYyzFmSCWVaYphYiFKEE2EwQPw2Mw9FPufo3Gl3KVOmyxTudkfneSQVR-j4l8QYTYl_ATiBtTF3rnCWHko0p0qfiWCsi5RnpUoMZV1iZXroR1_jHcm6Txta5U-anXltMpsoXKdug4ThFDGYIXNG2zrSvVlOl0VVVpmzqORoLyOF81Rb9Fh-lsV0uT4DzDflAE</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>UMEZAWA, IWAO</creator><creator>OKA, HIROFUMI</creator><creator>KOMIYAMA, KANKI</creator><creator>HAGIWARA, KEIKO</creator><creator>TOMISAKA, SHIGERU</creator><creator>MIYANO, TETSUJI</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>A NEW ANTITUMOR ANTIBIOTIC, AWAMYCIN</title><author>UMEZAWA, IWAO ; OKA, HIROFUMI ; KOMIYAMA, KANKI ; HAGIWARA, KEIKO ; TOMISAKA, SHIGERU ; MIYANO, TETSUJI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5814-ebf948ad7cd8f639bb04ae294784fef4f9971beff83371ad581530df01d16d9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Antibiotics</topic><topic>Antibiotics, Antineoplastic - isolation & purification</topic><topic>Antibiotics. 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Drug treatments</topic><topic>Production of active biomolecules</topic><topic>Quinones - isolation & purification</topic><topic>Quinones - therapeutic use</topic><topic>Sarcoma 180 - drug therapy</topic><topic>Streptomyces</topic><topic>Streptomyces - growth & development</topic><topic>Streptomyces - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>UMEZAWA, IWAO</creatorcontrib><creatorcontrib>OKA, HIROFUMI</creatorcontrib><creatorcontrib>KOMIYAMA, KANKI</creatorcontrib><creatorcontrib>HAGIWARA, KEIKO</creatorcontrib><creatorcontrib>TOMISAKA, SHIGERU</creatorcontrib><creatorcontrib>MIYANO, TETSUJI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>UMEZAWA, IWAO</au><au>OKA, HIROFUMI</au><au>KOMIYAMA, KANKI</au><au>HAGIWARA, KEIKO</au><au>TOMISAKA, SHIGERU</au><au>MIYANO, TETSUJI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A NEW ANTITUMOR ANTIBIOTIC, AWAMYCIN</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1983</date><risdate>1983</risdate><volume>36</volume><issue>9</issue><spage>1144</spage><epage>1149</epage><pages>1144-1149</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>A new antibiotic, awamycin, was isolated from the culture broth of Streptomyces sp. No. 80-217. It appeared to belong to the quinone indicator group from results of physicochemical studies and has the empirical formula C38H49NO12S. This antibiotic possessed antibacterial and antitumor activities against Gram-positive bacteria and experimental murine tumors. The antibiotic also showed direct cytotoxic activity against HeLa cells in vitro.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>6688804</pmid><doi>10.7164/antibiotics.36.1144</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1983, Vol.36(9), pp.1144-1149 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80714669 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Animals Antibiotics Antibiotics, Antineoplastic - isolation & purification Antibiotics. Antiinfectious agents. Antiparasitic agents awamycin Biological and medical sciences Biotechnology Carcinoma - drug therapy Fermentation Fundamental and applied biological sciences. Psychology gram-positive bacteria Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Male Medical sciences Mice Mice, Inbred ICR Miscellaneous. Antibiotics with multiple activities Pharmacology. Drug treatments Production of active biomolecules Quinones - isolation & purification Quinones - therapeutic use Sarcoma 180 - drug therapy Streptomyces Streptomyces - growth & development Streptomyces - ultrastructure |
| title | A NEW ANTITUMOR ANTIBIOTIC, AWAMYCIN |
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