A NEW ANTITUMOR ANTIBIOTIC, AWAMYCIN

A new antibiotic, awamycin, was isolated from the culture broth of Streptomyces sp. No. 80-217. It appeared to belong to the quinone indicator group from results of physicochemical studies and has the empirical formula C38H49NO12S. This antibiotic possessed antibacterial and antitumor activities aga...

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Veröffentlicht in:	Journal of antibiotics 1983, Vol.36(9), pp.1144-1149
Hauptverfasser:	UMEZAWA, IWAO, OKA, HIROFUMI, KOMIYAMA, KANKI, HAGIWARA, KEIKO, TOMISAKA, SHIGERU, MIYANO, TETSUJI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Antibiotics, Antineoplastic - isolation & purification Antibiotics. Antiinfectious agents. Antiparasitic agents awamycin Biological and medical sciences Biotechnology Carcinoma - drug therapy Fermentation Fundamental and applied biological sciences. Psychology gram-positive bacteria Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Male Medical sciences Mice Mice, Inbred ICR Miscellaneous. Antibiotics with multiple activities Pharmacology. Drug treatments Production of active biomolecules Quinones - isolation & purification Quinones - therapeutic use Sarcoma 180 - drug therapy Streptomyces Streptomyces - growth & development Streptomyces - ultrastructure
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Zusammenfassung:	A new antibiotic, awamycin, was isolated from the culture broth of Streptomyces sp. No. 80-217. It appeared to belong to the quinone indicator group from results of physicochemical studies and has the empirical formula C38H49NO12S. This antibiotic possessed antibacterial and antitumor activities against Gram-positive bacteria and experimental murine tumors. The antibiotic also showed direct cytotoxic activity against HeLa cells in vitro.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.36.1144