Glycophorin A Inhibits Lysis by the Complement Attack Phase

A glycoprotein from human erythrocyte membranes has been found to inhibit lysis of target cells by the attack-phase components C5-C9 from human complement. The inhibiting molecule was purified and identified as glycophorin A. Thus, glycophorin A may have a regulatory function in the lytic complement...

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Veröffentlicht in:	Immunobiology (1979) 1983-08, Vol.165 (2), p.115-120
Hauptverfasser:	Brauch, Hiltrud, Roelcke, D., Rother, Ursula
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Cell interactions Chickens Complement Inactivator Proteins - physiology Complement Membrane Attack Complex Complement System Proteins - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Glycophorin - immunology Glycophorin - isolation & purification Glycophorin - physiology Guinea Pigs Hemolysis Humans Immune Tolerance Immunobiology MNSs Blood-Group System Sialoglycoproteins - physiology
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Beschreibung
Zusammenfassung:	A glycoprotein from human erythrocyte membranes has been found to inhibit lysis of target cells by the attack-phase components C5-C9 from human complement. The inhibiting molecule was purified and identified as glycophorin A. Thus, glycophorin A may have a regulatory function in the lytic complement attack on isologous cells.
ISSN:	0171-2985 1878-3279
DOI:	10.1016/S0171-2985(83)80053-9