Potassium Ion Channels Operated by Receptor Stimulation Can be Activated Simply by Raising Temperature
Application of either dopamine (DA), acetylcholine (ACh), or histamine (HA) to the identified ganglion cells of Aplysia elicits a K(+)-dependent slow hyperpolarization. When temperature of the bathing solution was raised from 22 to 32 degrees C, these cells were also hyperpolarized with a marked inc...
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| Veröffentlicht in: | Japanese journal of physiology 1991, Vol.41(1), pp.117-127 |
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| container_title | Japanese journal of physiology |
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| creator | TAMAZAWA, Yoshiaki MATSUMOTO, Mitsuhiko KUDO, Atsuko SASAKI, Kazuhiko |
| description | Application of either dopamine (DA), acetylcholine (ACh), or histamine (HA) to the identified ganglion cells of Aplysia elicits a K(+)-dependent slow hyperpolarization. When temperature of the bathing solution was raised from 22 to 32 degrees C, these cells were also hyperpolarized with a marked increase in K+ conductance. The warm- and transmitter-induced current responses recorded under voltage clamp were not blocked by either 1 mM Ba2+ or 10 mM TEA. Intracellularly injected guanosine 5'-O-(2-thiodiphosphate) (GDP beta S) depressed both warm- and transmitter-induced K+ responses immediately after the injection. Intracellular application of guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) caused a gradual, irreversible increase in K+ conductance of the plasma membrane and occluded both responses. Transmitter-induced response markedly decreased when the temperature was raised from 22 to 32 degrees C, suggesting that the response to transmitter was occluded during the warm-induced response. These results suggested that the G-protein regulating the receptor-operated K+ channels could be activated simply by raising temperature. |
| doi_str_mv | 10.2170/jjphysiol.41.117 |
| format | Article |
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When temperature of the bathing solution was raised from 22 to 32 degrees C, these cells were also hyperpolarized with a marked increase in K+ conductance. The warm- and transmitter-induced current responses recorded under voltage clamp were not blocked by either 1 mM Ba2+ or 10 mM TEA. Intracellularly injected guanosine 5'-O-(2-thiodiphosphate) (GDP beta S) depressed both warm- and transmitter-induced K+ responses immediately after the injection. Intracellular application of guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) caused a gradual, irreversible increase in K+ conductance of the plasma membrane and occluded both responses. Transmitter-induced response markedly decreased when the temperature was raised from 22 to 32 degrees C, suggesting that the response to transmitter was occluded during the warm-induced response. These results suggested that the G-protein regulating the receptor-operated K+ channels could be activated simply by raising temperature.</description><identifier>ISSN: 0021-521X</identifier><identifier>EISSN: 1881-1396</identifier><identifier>DOI: 10.2170/jjphysiol.41.117</identifier><identifier>PMID: 1649930</identifier><identifier>CODEN: JJPHAM</identifier><language>eng</language><publisher>Tokyo: THE PHYSIOLOGICAL SOCIETY OF JAPAN</publisher><subject>Acetylcholine - pharmacology ; acetylcholine receptor ; Animals ; Aplysia ; Aplysia - physiology ; Barium - metabolism ; Biochemistry. Physiology. Immunology ; Biological and medical sciences ; cell membranes ; Dopamine - pharmacology ; dopamine receptor ; Electric Conductivity - drug effects ; Electric Conductivity - physiology ; electrophysiology ; Fundamental and applied biological sciences. Psychology ; GTP-binding protein ; GTP-Binding Proteins - physiology ; Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology ; Guanosine Diphosphate - analogs & derivatives ; Guanosine Diphosphate - pharmacology ; Histamine - pharmacology ; Invertebrates ; Marine ; marine molluscs ; Mollusca ; Neurons - drug effects ; Neurons - physiology ; Physiology. Development ; potassium ; Potassium - metabolism ; potassium channel ; Potassium Channels - drug effects ; Potassium Channels - physiology ; receptors ; Receptors, Neurotransmitter - drug effects ; Receptors, Neurotransmitter - physiology ; Temperature ; temperature effect ; temperature effects ; Tetraethylammonium ; Tetraethylammonium Compounds - pharmacology ; Thionucleotides - pharmacology</subject><ispartof>The Japanese Journal of Physiology, 1991, Vol.41(1), pp.117-127</ispartof><rights>1991 by The Physiological Society of Japan</rights><rights>1992 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5601445$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1649930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAMAZAWA, Yoshiaki</creatorcontrib><creatorcontrib>MATSUMOTO, Mitsuhiko</creatorcontrib><creatorcontrib>KUDO, Atsuko</creatorcontrib><creatorcontrib>SASAKI, Kazuhiko</creatorcontrib><title>Potassium Ion Channels Operated by Receptor Stimulation Can be Activated Simply by Raising Temperature</title><title>Japanese journal of physiology</title><addtitle>Jpn J Physiol</addtitle><description>Application of either dopamine (DA), acetylcholine (ACh), or histamine (HA) to the identified ganglion cells of Aplysia elicits a K(+)-dependent slow hyperpolarization. When temperature of the bathing solution was raised from 22 to 32 degrees C, these cells were also hyperpolarized with a marked increase in K+ conductance. The warm- and transmitter-induced current responses recorded under voltage clamp were not blocked by either 1 mM Ba2+ or 10 mM TEA. Intracellularly injected guanosine 5'-O-(2-thiodiphosphate) (GDP beta S) depressed both warm- and transmitter-induced K+ responses immediately after the injection. Intracellular application of guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) caused a gradual, irreversible increase in K+ conductance of the plasma membrane and occluded both responses. Transmitter-induced response markedly decreased when the temperature was raised from 22 to 32 degrees C, suggesting that the response to transmitter was occluded during the warm-induced response. These results suggested that the G-protein regulating the receptor-operated K+ channels could be activated simply by raising temperature.</description><subject>Acetylcholine - pharmacology</subject><subject>acetylcholine receptor</subject><subject>Animals</subject><subject>Aplysia</subject><subject>Aplysia - physiology</subject><subject>Barium - metabolism</subject><subject>Biochemistry. Physiology. Immunology</subject><subject>Biological and medical sciences</subject><subject>cell membranes</subject><subject>Dopamine - pharmacology</subject><subject>dopamine receptor</subject><subject>Electric Conductivity - drug effects</subject><subject>Electric Conductivity - physiology</subject><subject>electrophysiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GTP-binding protein</subject><subject>GTP-Binding Proteins - physiology</subject><subject>Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology</subject><subject>Guanosine Diphosphate - analogs & derivatives</subject><subject>Guanosine Diphosphate - pharmacology</subject><subject>Histamine - pharmacology</subject><subject>Invertebrates</subject><subject>Marine</subject><subject>marine molluscs</subject><subject>Mollusca</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Physiology. Development</subject><subject>potassium</subject><subject>Potassium - metabolism</subject><subject>potassium channel</subject><subject>Potassium Channels - drug effects</subject><subject>Potassium Channels - physiology</subject><subject>receptors</subject><subject>Receptors, Neurotransmitter - drug effects</subject><subject>Receptors, Neurotransmitter - physiology</subject><subject>Temperature</subject><subject>temperature effect</subject><subject>temperature effects</subject><subject>Tetraethylammonium</subject><subject>Tetraethylammonium Compounds - pharmacology</subject><subject>Thionucleotides - pharmacology</subject><issn>0021-521X</issn><issn>1881-1396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuL3DAMgE1p2U63vfdS8KHsLVMrcRznuAzb7cLCln1Ab0HxKDsOzqO2U5h_X3dmmGsvEuL7kITE2GcQ6xwq8a3v590-2MmtJawBqjdsBVpDBkWt3rKVEDlkZQ6_3rMPIfSpVFLJC3YBStZ1IVas-zlFDMEuA7-bRr7Z4TiSC_xhJo-Rtrzd80cyNMfJ86doh8VhtP9MHHlL_NpE--cgPtlhdvuDjzbY8ZU_03Dosnj6yN516AJ9OuVL9vL95nnzI7t_uL3bXN9nfZHrmFG3bTvR1VWOGqAVKSphjFSqLYu0egUmkVJSJY2SAo1B3ZYgNdSaNFBxya6OfWc__V4oxGawwZBzONK0hEaLSkhVwH_FNLfSssyT-OUkLu1A22b2dkC_b04XTPzriWMw6DqPo7HhrJVKgJRl0m6OWh8ivtKZo4_WOGrOj2wkNHAM6Z9nbnboGxqLvzXfmuc</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>TAMAZAWA, Yoshiaki</creator><creator>MATSUMOTO, Mitsuhiko</creator><creator>KUDO, Atsuko</creator><creator>SASAKI, Kazuhiko</creator><general>THE PHYSIOLOGICAL SOCIETY OF JAPAN</general><general>Center for Academic Publications Japan</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Potassium Ion Channels Operated by Receptor Stimulation Can be Activated Simply by Raising Temperature</title><author>TAMAZAWA, Yoshiaki ; MATSUMOTO, Mitsuhiko ; KUDO, Atsuko ; SASAKI, Kazuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j328t-efdbf0f972a811b0a8160cc466b5364671c2a854e74c640acca8b5148198e81e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Acetylcholine - pharmacology</topic><topic>acetylcholine receptor</topic><topic>Animals</topic><topic>Aplysia</topic><topic>Aplysia - physiology</topic><topic>Barium - metabolism</topic><topic>Biochemistry. Physiology. Immunology</topic><topic>Biological and medical sciences</topic><topic>cell membranes</topic><topic>Dopamine - pharmacology</topic><topic>dopamine receptor</topic><topic>Electric Conductivity - drug effects</topic><topic>Electric Conductivity - physiology</topic><topic>electrophysiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GTP-binding protein</topic><topic>GTP-Binding Proteins - physiology</topic><topic>Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology</topic><topic>Guanosine Diphosphate - analogs & derivatives</topic><topic>Guanosine Diphosphate - pharmacology</topic><topic>Histamine - pharmacology</topic><topic>Invertebrates</topic><topic>Marine</topic><topic>marine molluscs</topic><topic>Mollusca</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Physiology. Development</topic><topic>potassium</topic><topic>Potassium - metabolism</topic><topic>potassium channel</topic><topic>Potassium Channels - drug effects</topic><topic>Potassium Channels - physiology</topic><topic>receptors</topic><topic>Receptors, Neurotransmitter - drug effects</topic><topic>Receptors, Neurotransmitter - physiology</topic><topic>Temperature</topic><topic>temperature effect</topic><topic>temperature effects</topic><topic>Tetraethylammonium</topic><topic>Tetraethylammonium Compounds - pharmacology</topic><topic>Thionucleotides - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>TAMAZAWA, Yoshiaki</creatorcontrib><creatorcontrib>MATSUMOTO, Mitsuhiko</creatorcontrib><creatorcontrib>KUDO, Atsuko</creatorcontrib><creatorcontrib>SASAKI, Kazuhiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAMAZAWA, Yoshiaki</au><au>MATSUMOTO, Mitsuhiko</au><au>KUDO, Atsuko</au><au>SASAKI, Kazuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potassium Ion Channels Operated by Receptor Stimulation Can be Activated Simply by Raising Temperature</atitle><jtitle>Japanese journal of physiology</jtitle><addtitle>Jpn J Physiol</addtitle><date>1991</date><risdate>1991</risdate><volume>41</volume><issue>1</issue><spage>117</spage><epage>127</epage><pages>117-127</pages><issn>0021-521X</issn><eissn>1881-1396</eissn><coden>JJPHAM</coden><abstract>Application of either dopamine (DA), acetylcholine (ACh), or histamine (HA) to the identified ganglion cells of Aplysia elicits a K(+)-dependent slow hyperpolarization. When temperature of the bathing solution was raised from 22 to 32 degrees C, these cells were also hyperpolarized with a marked increase in K+ conductance. The warm- and transmitter-induced current responses recorded under voltage clamp were not blocked by either 1 mM Ba2+ or 10 mM TEA. Intracellularly injected guanosine 5'-O-(2-thiodiphosphate) (GDP beta S) depressed both warm- and transmitter-induced K+ responses immediately after the injection. Intracellular application of guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) caused a gradual, irreversible increase in K+ conductance of the plasma membrane and occluded both responses. Transmitter-induced response markedly decreased when the temperature was raised from 22 to 32 degrees C, suggesting that the response to transmitter was occluded during the warm-induced response. These results suggested that the G-protein regulating the receptor-operated K+ channels could be activated simply by raising temperature.</abstract><cop>Tokyo</cop><pub>THE PHYSIOLOGICAL SOCIETY OF JAPAN</pub><pmid>1649930</pmid><doi>10.2170/jjphysiol.41.117</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Japanese Journal of Physiology, 1991, Vol.41(1), pp.117-127 |
| issn | 0021-521X 1881-1396 |
| language | eng |
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| subjects | Acetylcholine - pharmacology acetylcholine receptor Animals Aplysia Aplysia - physiology Barium - metabolism Biochemistry. Physiology. Immunology Biological and medical sciences cell membranes Dopamine - pharmacology dopamine receptor Electric Conductivity - drug effects Electric Conductivity - physiology electrophysiology Fundamental and applied biological sciences. Psychology GTP-binding protein GTP-Binding Proteins - physiology Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Guanosine Diphosphate - analogs & derivatives Guanosine Diphosphate - pharmacology Histamine - pharmacology Invertebrates Marine marine molluscs Mollusca Neurons - drug effects Neurons - physiology Physiology. Development potassium Potassium - metabolism potassium channel Potassium Channels - drug effects Potassium Channels - physiology receptors Receptors, Neurotransmitter - drug effects Receptors, Neurotransmitter - physiology Temperature temperature effect temperature effects Tetraethylammonium Tetraethylammonium Compounds - pharmacology Thionucleotides - pharmacology |
| title | Potassium Ion Channels Operated by Receptor Stimulation Can be Activated Simply by Raising Temperature |
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