Malignant histiocytosis

The clinical features, therapy, and hospital course of ten consecutive patients with malignant histiocytosis (MH) are presented. The value of bone marrow aspiration for the diagnosis is discussed. The patient's performance status as described in this report by the organ dysfunction score may pr...

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Veröffentlicht in:	Cancer 1983-11, Vol.52 (10), p.1904-1910
Hauptverfasser:	Esseltine, Dixie W., De Leeuw, NANNIE K. M., Berry, Gerry R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Autopsy Biological and medical sciences Blood Cell Count Bone Marrow - pathology Fever - pathology Hematologic and hematopoietic diseases Hepatomegaly Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - pathology Lymphatic Diseases - drug therapy Lymphatic Diseases - pathology Macrophages - pathology Male Medical sciences Middle Aged Radiography Respiratory Tract Diseases - diagnostic imaging Respiratory Tract Diseases - pathology Splenomegaly
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Beschreibung
Zusammenfassung:	The clinical features, therapy, and hospital course of ten consecutive patients with malignant histiocytosis (MH) are presented. The value of bone marrow aspiration for the diagnosis is discussed. The patient's performance status as described in this report by the organ dysfunction score may predict survival and response to chemotherapy. The literature on chemotherapy in this disease is reviewed. Combination chemotherapy may be the best approach to treatment, but there is little experience with single agents. There is a great need for better characterization of the malignant cell in this disorder.
ISSN:	0008-543X 1097-0142
DOI:	10.1002/1097-0142(19831115)52:10<1904::AID-CNCR2820521022>3.0.CO;2-K