Antitumor activity of diterpenoids, trichorabdals A, B, and C, and the related compounds: synergism of two active sites

Antitumor activity of Rabdosia diterpenoids and the related compounds against Ehrlich ascites carcinoma has been studied. In addition to α-methylene cyclopentanone moiety, spirolactone aldehyde grouping functions as an active site in these compounds. Significant increase in activity can be attribute...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1983/04/25, Vol.31(4), pp.1433-1436
Hauptverfasser:	Node, M, Sai, M, Fuji, K, Fujita, E, Takeda, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic Binding Sites Diterpenes - pharmacology Mice nonfood plant products synergism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Antitumor activity of Rabdosia diterpenoids and the related compounds against Ehrlich ascites carcinoma has been studied. In addition to α-methylene cyclopentanone moiety, spirolactone aldehyde grouping functions as an active site in these compounds. Significant increase in activity can be attributed to synergism of two active sites in the molecule.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.31.1433