Effect of Temperature on the Metabolism of Aminopyrine

Effect of Temperature on the Metabolism of Aminopyrine

We examined the effect of temperature on the fate of aminopyrine (AM) by using five male rabbits kept at 15 or 30°C. The rabbits kept at 15°C showed an increase in elimination of plasma AM compared with those at 30°C. The total urinary excretion of AM and its metabolites at 15°C was smaller than tha...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1983/04/25, Vol.31(4), pp.1404-1407
Hauptverfasser: MATSUYAMA, KENJI, TAKENAKA, SHIGEYUKI, NODA, ATSUKO, IGUCHI, SADAO
Format: Artikel
Sprache:eng
Schlagworte:
Aminopyrine - metabolism
Animals
Male
plasma concentration
Rabbits
Temperature
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Zusammenfassung:We examined the effect of temperature on the fate of aminopyrine (AM) by using five male rabbits kept at 15 or 30°C. The rabbits kept at 15°C showed an increase in elimination of plasma AM compared with those at 30°C. The total urinary excretion of AM and its metabolites at 15°C was smaller than that at 30°C.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.31.1404