Dopamine receptors in the denervated striatum: further supersensitivity by chronic haloperidol treatment
The authors have studied the effects of chronic haloperidol exposure and denervation on rat striatal DA receptors. Effects of denervation and receptor blockade on the striatal membrane binding of the putative D2 dopmaine radioligand, ( super(3)H)spiperone, were found to be additive. As in the nucleu...
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| Veröffentlicht in: | Brain research 1983-09, Vol.275 (1), p.183-185 |
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| container_end_page | 185 |
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| container_title | Brain research |
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| creator | Reches, A. Wagner, R.H. Jackson, V. Yablonskaya-Alter, E. Fahn, S. |
| description | The authors have studied the effects of chronic haloperidol exposure and denervation on rat striatal DA receptors. Effects of denervation and receptor blockade on the striatal membrane binding of the putative D2 dopmaine radioligand, ( super(3)H)spiperone, were found to be additive. As in the nucleus accumbens, DA receptor up-regulation after receptor blokage or denervation may occur through separate mechanisms. |
| doi_str_mv | 10.1016/0006-8993(83)90434-1 |
| format | Article |
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Effects of denervation and receptor blockade on the striatal membrane binding of the putative D2 dopmaine radioligand, ( super(3)H)spiperone, were found to be additive. As in the nucleus accumbens, DA receptor up-regulation after receptor blokage or denervation may occur through separate mechanisms.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(83)90434-1</identifier><identifier>PMID: 6414646</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Corpus Striatum - drug effects ; denervation ; dopamine ; dopamine receptor ; haloperidol ; Haloperidol - pharmacology ; Hydroxydopamines - pharmacology ; Male ; Medical sciences ; neuroleptics ; Neuropharmacology ; Oxidopamine ; Pharmacology. Drug treatments ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine - drug effects ; striate cortex ; striatum</subject><ispartof>Brain research, 1983-09, Vol.275 (1), p.183-185</ispartof><rights>1983 Elsevier Science Publishers B.V., Amsterdam</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-c166a822ffbb87070f85c0007bf542178a68d15681e0e8e5f65e78932536033d3</citedby><cites>FETCH-LOGICAL-c398t-c166a822ffbb87070f85c0007bf542178a68d15681e0e8e5f65e78932536033d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(83)90434-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9384346$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6414646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reches, A.</creatorcontrib><creatorcontrib>Wagner, R.H.</creatorcontrib><creatorcontrib>Jackson, V.</creatorcontrib><creatorcontrib>Yablonskaya-Alter, E.</creatorcontrib><creatorcontrib>Fahn, S.</creatorcontrib><title>Dopamine receptors in the denervated striatum: further supersensitivity by chronic haloperidol treatment</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The authors have studied the effects of chronic haloperidol exposure and denervation on rat striatal DA receptors. Effects of denervation and receptor blockade on the striatal membrane binding of the putative D2 dopmaine radioligand, ( super(3)H)spiperone, were found to be additive. As in the nucleus accumbens, DA receptor up-regulation after receptor blokage or denervation may occur through separate mechanisms.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Corpus Striatum - drug effects</subject><subject>denervation</subject><subject>dopamine</subject><subject>dopamine receptor</subject><subject>haloperidol</subject><subject>Haloperidol - pharmacology</subject><subject>Hydroxydopamines - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>neuroleptics</subject><subject>Neuropharmacology</subject><subject>Oxidopamine</subject><subject>Pharmacology. Drug treatments</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Dopamine - drug effects</subject><subject>striate cortex</subject><subject>striatum</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1q3DAUhUVJSKfTvkELWoTSLpxKli1LWRRCfguBbNq1kOUrRsWWXEkemLevJjPMsl0Jcb5zufcchD5SckUJ5d8IIbwSUrIvgn2VpGFNRd-gFRVdXfG6IWdodULeoncp_S5fxiS5QBe8oQ1v-Apt7sKsJ-cBRzAw5xATdh7nDeABPMStzjDglKPTeZmusV1i0SJOywwxgU8uu63LO9zvsNnE4J3BGz2GorohjDhH0HkCn9-jc6vHBB-O7xr9erj_eftUPb88_ri9ea4MkyJXhnKuRV1b2_eiIx2xojVl7663bVPTTmguBtpyQYGAgNbyFjohWd0yXo4b2Bp9PsydY_izQMpqcsnAOGoPYUlKEC6Lu_0vSBkvKUpSwOYAmhhSimDVHN2k405RovZNqH3Mah-zEky9NlHca_TpOH_pJxhOpmP0Rb886joZPdqovXHphEkmypw99v2AQQlt6yCqZBx4A4MrjWU1BPfvPf4C7gGlfQ</recordid><startdate>19830919</startdate><enddate>19830919</enddate><creator>Reches, A.</creator><creator>Wagner, R.H.</creator><creator>Jackson, V.</creator><creator>Yablonskaya-Alter, E.</creator><creator>Fahn, S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19830919</creationdate><title>Dopamine receptors in the denervated striatum: further supersensitivity by chronic haloperidol treatment</title><author>Reches, A. ; Wagner, R.H. ; Jackson, V. ; Yablonskaya-Alter, E. ; Fahn, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-c166a822ffbb87070f85c0007bf542178a68d15681e0e8e5f65e78932536033d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Corpus Striatum - drug effects</topic><topic>denervation</topic><topic>dopamine</topic><topic>dopamine receptor</topic><topic>haloperidol</topic><topic>Haloperidol - pharmacology</topic><topic>Hydroxydopamines - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>neuroleptics</topic><topic>Neuropharmacology</topic><topic>Oxidopamine</topic><topic>Pharmacology. Drug treatments</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Dopamine - drug effects</topic><topic>striate cortex</topic><topic>striatum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reches, A.</creatorcontrib><creatorcontrib>Wagner, R.H.</creatorcontrib><creatorcontrib>Jackson, V.</creatorcontrib><creatorcontrib>Yablonskaya-Alter, E.</creatorcontrib><creatorcontrib>Fahn, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reches, A.</au><au>Wagner, R.H.</au><au>Jackson, V.</au><au>Yablonskaya-Alter, E.</au><au>Fahn, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopamine receptors in the denervated striatum: further supersensitivity by chronic haloperidol treatment</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1983-09-19</date><risdate>1983</risdate><volume>275</volume><issue>1</issue><spage>183</spage><epage>185</epage><pages>183-185</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The authors have studied the effects of chronic haloperidol exposure and denervation on rat striatal DA receptors. Effects of denervation and receptor blockade on the striatal membrane binding of the putative D2 dopmaine radioligand, ( super(3)H)spiperone, were found to be additive. As in the nucleus accumbens, DA receptor up-regulation after receptor blokage or denervation may occur through separate mechanisms.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>6414646</pmid><doi>10.1016/0006-8993(83)90434-1</doi><tpages>3</tpages></addata></record> |
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| ispartof | Brain research, 1983-09, Vol.275 (1), p.183-185 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Corpus Striatum - drug effects denervation dopamine dopamine receptor haloperidol Haloperidol - pharmacology Hydroxydopamines - pharmacology Male Medical sciences neuroleptics Neuropharmacology Oxidopamine Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Receptors, Dopamine - drug effects striate cortex striatum |
| title | Dopamine receptors in the denervated striatum: further supersensitivity by chronic haloperidol treatment |
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