Dopamine receptors in the denervated striatum: further supersensitivity by chronic haloperidol treatment

Dopamine receptors in the denervated striatum: further supersensitivity by chronic haloperidol treatment

The authors have studied the effects of chronic haloperidol exposure and denervation on rat striatal DA receptors. Effects of denervation and receptor blockade on the striatal membrane binding of the putative D2 dopmaine radioligand, ( super(3)H)spiperone, were found to be additive. As in the nucleu...

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Veröffentlicht in:Brain research 1983-09, Vol.275 (1), p.183-185
Hauptverfasser: Reches, A., Wagner, R.H., Jackson, V., Yablonskaya-Alter, E., Fahn, S.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Corpus Striatum - drug effects
denervation
dopamine
dopamine receptor
haloperidol
Haloperidol - pharmacology
Hydroxydopamines - pharmacology
Male
Medical sciences
neuroleptics
Neuropharmacology
Oxidopamine
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Inbred Strains
Receptors, Dopamine - drug effects
striate cortex
striatum
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Zusammenfassung:The authors have studied the effects of chronic haloperidol exposure and denervation on rat striatal DA receptors. Effects of denervation and receptor blockade on the striatal membrane binding of the putative D2 dopmaine radioligand, ( super(3)H)spiperone, were found to be additive. As in the nucleus accumbens, DA receptor up-regulation after receptor blokage or denervation may occur through separate mechanisms.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(83)90434-1