A case of familial mediterranean fever with cutaneous vasculitis and immune complex nephritis: light, electron, and immunofluorescent study of renal biopsy

A 29-year-old patient suffering from familial Mediterranean fever developed severe myalgia and hematuria. Skin biopsy showed vasculitis. The kidney biopsy revealed diffuse proliferative and exudative glomerulonephritis. On immunofluorescent examination, IgM deposits accompanied by C3 were found in c...

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Veröffentlicht in:	American journal of clinical pathology 1983-10, Vol.80 (4), p.511-514
Hauptverfasser:	SCHLESINGER, M, KOPOLOVIC, J, VISKOPER, R. J, RON, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigen-Antibody Complex - analysis Arteries - pathology Biological and medical sciences Familial Mediterranean Fever - complications Familial Mediterranean Fever - pathology Fluorescent Antibody Technique Glomerulonephritis - complications Glomerulonephritis - immunology Glomerulonephritis - pathology Humans Immunoglobulin M - analysis Kidney Glomerulus - ultrastructure Male Medical sciences Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Vasculitis - complications Vasculitis - pathology
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Zusammenfassung:	A 29-year-old patient suffering from familial Mediterranean fever developed severe myalgia and hematuria. Skin biopsy showed vasculitis. The kidney biopsy revealed diffuse proliferative and exudative glomerulonephritis. On immunofluorescent examination, IgM deposits accompanied by C3 were found in coarse granular peripheral distribution. Electron microscopy revealed glomerular subepithelial deposits. Familial Mediterranean fever with vasculitis and immune complex nephritis is discussed.
ISSN:	0002-9173 1943-7722
DOI:	10.1093/ajcp/80.4.511