Mononuclear Cell Leukemia in Aged Sprague-Dawley Rats

A mononuclear cell leukemia in Sprague-Dawley rats is described in which liver, spleen, and lung involvement was a constant feature. The cell was 16 to 25 μm in diameter with round, oval or indented nucleus, and the cytoplasm contained bright red granules. This is the first report of such a leukemia...

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Veröffentlicht in:	Veterinary pathology 1983-07, Vol.20 (4), p.434-439
Hauptverfasser:	Abbott, D. P., Prentice, D. E., Cherry, C. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Female Leukemia - pathology Leukemia - veterinary Leukemia, Experimental - pathology Liver - pathology Lung - pathology Male Monocytes - ultrastructure Rats Rats, Inbred Strains Rats, Inbred WF Rodent Diseases - pathology Spleen - pathology
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Beschreibung
Zusammenfassung:	A mononuclear cell leukemia in Sprague-Dawley rats is described in which liver, spleen, and lung involvement was a constant feature. The cell was 16 to 25 μm in diameter with round, oval or indented nucleus, and the cytoplasm contained bright red granules. This is the first report of such a leukemia in Sprague-Dawley rats and a comparison with mononuclear cell leukemia in other strains of laboratory rats is made.
ISSN:	0300-9858 1544-2217
DOI:	10.1177/030098588302000406