Formation of Pyrazine Derivatives from D-Glucosamine and Their Deoxyribonucleic Acid (DNA) Strand Breakage Activity

Two pyrazine derivatives [fructosazine (3) and deoxyfructosazine (6)] were simultaneously formed in a solution of D-glucosamine hydrochloride under various conditions. They showed deoxyribonucleic acid (DNA) strand breakage activity in plasmid pBR322 comparable to that of D-glucosamine. The DNA stra...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1991/03/25, Vol.39(3), pp.792-794
Hauptverfasser:	SUMOTO, Kunihiro, IRIE, Michiko, MIBU, Nobuko, MIYANO, Seiji, NAKASHIMA, Yukihiko, WATANABE, Kenji, YAMAGUCHI, Tadatoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	aminosugar Chemistry copper ion D-glucosamine deoxyfructosazine DNA Damage DNA strand breakage Escherichia coli Exact sciences and technology fructosazine Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings L-cysteine Organic chemistry plasmid pBR322 Preparations and properties pyrazine Pyrazines - chemistry Pyrazines - pharmacology
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Zusammenfassung:	Two pyrazine derivatives [fructosazine (3) and deoxyfructosazine (6)] were simultaneously formed in a solution of D-glucosamine hydrochloride under various conditions. They showed deoxyribonucleic acid (DNA) strand breakage activity in plasmid pBR322 comparable to that of D-glucosamine. The DNA strand breakage by fructosazine (3) was stimulated by Cu2+.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.39.792