MODIFICATION BY CADMIUM IONS OF 45CALCIUM UPTAKE BY ISOLATED RABBIT AORTAE

MODIFICATION BY CADMIUM IONS OF 45CALCIUM UPTAKE BY ISOLATED RABBIT AORTAE

Treatment with 0.5 mM Cd++ suppressed the K+ (30 mM)-stimulated uptake and influx of 45Ca and abolished the K+-induced contraction in helical strips of rabbit aortae. The rapid and slow efflux of 45Ca previously accumulated was not appreciably affected by Cd++. It is concluded that interference with...

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Veröffentlicht in:Japanese journal of pharmacology 1983, Vol.33(3), pp.655-658
Hauptverfasser: HATTORI, Keisuke, SHIMOURA, Keiko, TODA, Noboru
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Aorta, Thoracic - physiology
Biological Transport
Cadmium - pharmacology
Calcium - metabolism
Female
In Vitro Techniques
Male
Muscle Contraction
Potassium - pharmacology
Rabbits
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Zusammenfassung:Treatment with 0.5 mM Cd++ suppressed the K+ (30 mM)-stimulated uptake and influx of 45Ca and abolished the K+-induced contraction in helical strips of rabbit aortae. The rapid and slow efflux of 45Ca previously accumulated was not appreciably affected by Cd++. It is concluded that interference with the transmembrane influx of Ca++ is a major mechanism of Cd++ action.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.33.655