Immunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity
We investigated the effect of immunotherapy (IT) on eosinophil (EOS) migration into the nasal cavity after nasal provocation with ragweed antigen and during seasonal exposure. In the first study, three groups of subjects participated: one group with no treatment (N = 19), one group with 10 months of...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 1991-07, Vol.88 (1), p.27-32 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Furin, Mark J. Norman, Philip S. Creticos, Peter S. Proud, David Kagey-Sobotka, Anne Lichtenstein, Lawrence M. Naclerio, Robert M. |
| description | We investigated the effect of immunotherapy (IT) on eosinophil (EOS) migration into the nasal cavity after nasal provocation with ragweed antigen and during seasonal exposure. In the first study, three groups of subjects participated: one group with no treatment (N = 19), one group with 10 months of IT, reaching maintenance at 2 μg of
Arab a I (antigen E) (N = 15), and one group with 22 months of IT, reaching maintenance at 24 μg of
Amb a I (N = 10). The percent of EOSs in nasal lavages performed during December before and 24 hours after nasal challenge with ragweed extract was determined. No significant difference between groups existed before challenge. The no-treatment group demonstrated a significant increase in the percent of EOSs from 26% to 69.5%
p < 0.008), whereas the treated groups demonstrated no significant change. In the second study, 45 patients were divided into four groups based on maintenance dose in micrograms of
Amb a I and duration of treatment: (1) no treatment (N = 15), (2) 1 year at 2 μg (N = 13), (3) 2 years at 2 μg (N = 11), and (4) 3 years at 24 μg (N = 9). Nasal mucosal brushings were done during the ragweed season. A significantly smaller percentage of EOSs in 3-year IT-treated individuals was obtained compared to the control group (18 versus 8.4;
p < 0.04). The smaller dose of IT, regardless of duration, did not reveal a reduction compared to that in the no-treatment group. These studies provide evidence that IT modifies the eosinophilic response to antigen exposure and demonstrate a parallel between in vivo provocation and seasonal exposure. |
| doi_str_mv | 10.1016/0091-6749(91)90297-2 |
| format | Article |
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Arab a I (antigen E) (N = 15), and one group with 22 months of IT, reaching maintenance at 24 μg of
Amb a I (N = 10). The percent of EOSs in nasal lavages performed during December before and 24 hours after nasal challenge with ragweed extract was determined. No significant difference between groups existed before challenge. The no-treatment group demonstrated a significant increase in the percent of EOSs from 26% to 69.5%
p < 0.008), whereas the treated groups demonstrated no significant change. In the second study, 45 patients were divided into four groups based on maintenance dose in micrograms of
Amb a I and duration of treatment: (1) no treatment (N = 15), (2) 1 year at 2 μg (N = 13), (3) 2 years at 2 μg (N = 11), and (4) 3 years at 24 μg (N = 9). Nasal mucosal brushings were done during the ragweed season. A significantly smaller percentage of EOSs in 3-year IT-treated individuals was obtained compared to the control group (18 versus 8.4;
p < 0.04). The smaller dose of IT, regardless of duration, did not reveal a reduction compared to that in the no-treatment group. These studies provide evidence that IT modifies the eosinophilic response to antigen exposure and demonstrate a parallel between in vivo provocation and seasonal exposure.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/0091-6749(91)90297-2</identifier><identifier>PMID: 2071783</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Allergic diseases ; allergic rhinitis ; Amb a I ; Antigens - administration & dosage ; Biological and medical sciences ; Cell Movement - immunology ; Dose-Response Relationship, Immunologic ; eosinophils ; Eosinophils - immunology ; Humans ; Immunopathology ; Immunotherapy ; Leukocyte Count ; Medical sciences ; Nasal Cavity - immunology ; Nasal Provocation Tests ; Pollen - immunology ; ragweed ; Respiratory and ent allergic diseases ; Rhinitis, Allergic, Seasonal - immunology ; Rhinitis, Allergic, Seasonal - therapy ; Seasons</subject><ispartof>Journal of allergy and clinical immunology, 1991-07, Vol.88 (1), p.27-32</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-6c03dfd6e09551dd9a5ce350292c8edb3dbd340617d7710e84ff24040936a0c63</citedby><cites>FETCH-LOGICAL-c463t-6c03dfd6e09551dd9a5ce350292c8edb3dbd340617d7710e84ff24040936a0c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-6749(91)90297-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5076904$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2071783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furin, Mark J.</creatorcontrib><creatorcontrib>Norman, Philip S.</creatorcontrib><creatorcontrib>Creticos, Peter S.</creatorcontrib><creatorcontrib>Proud, David</creatorcontrib><creatorcontrib>Kagey-Sobotka, Anne</creatorcontrib><creatorcontrib>Lichtenstein, Lawrence M.</creatorcontrib><creatorcontrib>Naclerio, Robert M.</creatorcontrib><title>Immunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>We investigated the effect of immunotherapy (IT) on eosinophil (EOS) migration into the nasal cavity after nasal provocation with ragweed antigen and during seasonal exposure. In the first study, three groups of subjects participated: one group with no treatment (N = 19), one group with 10 months of IT, reaching maintenance at 2 μg of
Arab a I (antigen E) (N = 15), and one group with 22 months of IT, reaching maintenance at 24 μg of
Amb a I (N = 10). The percent of EOSs in nasal lavages performed during December before and 24 hours after nasal challenge with ragweed extract was determined. No significant difference between groups existed before challenge. The no-treatment group demonstrated a significant increase in the percent of EOSs from 26% to 69.5%
p < 0.008), whereas the treated groups demonstrated no significant change. In the second study, 45 patients were divided into four groups based on maintenance dose in micrograms of
Amb a I and duration of treatment: (1) no treatment (N = 15), (2) 1 year at 2 μg (N = 13), (3) 2 years at 2 μg (N = 11), and (4) 3 years at 24 μg (N = 9). Nasal mucosal brushings were done during the ragweed season. A significantly smaller percentage of EOSs in 3-year IT-treated individuals was obtained compared to the control group (18 versus 8.4;
p < 0.04). The smaller dose of IT, regardless of duration, did not reveal a reduction compared to that in the no-treatment group. These studies provide evidence that IT modifies the eosinophilic response to antigen exposure and demonstrate a parallel between in vivo provocation and seasonal exposure.</description><subject>Allergic diseases</subject><subject>allergic rhinitis</subject><subject>Amb a I</subject><subject>Antigens - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Cell Movement - immunology</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>eosinophils</subject><subject>Eosinophils - immunology</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Immunotherapy</subject><subject>Leukocyte Count</subject><subject>Medical sciences</subject><subject>Nasal Cavity - immunology</subject><subject>Nasal Provocation Tests</subject><subject>Pollen - immunology</subject><subject>ragweed</subject><subject>Respiratory and ent allergic diseases</subject><subject>Rhinitis, Allergic, Seasonal - immunology</subject><subject>Rhinitis, Allergic, Seasonal - therapy</subject><subject>Seasons</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFLJDEQhcPiouPs_gOFPojooXcrne6kcxFE1BWEvSgeQyap1kh3Mibdwvx7M84wRz1VwvvqUfWKkCMKfyhQ_hdA0pKLWp5Jei6hkqKsfpAZhfzgbdXskdkOOSCHKb1C_rNW7pP9CgQVLZuRp7thmHwYXzDq5aqwaCLqhKnQfnTP6Evn7WTQFhiS82H54vrCYN8Xg3uOenTBF86PocgGhddJZ1W_u3H1i_zsdJ_w97bOyePN9cPVv_L-_-3d1eV9aWrOxpIbYLazHEE2DbVW6sYga_IylWnRLphdWFYDp8IKQQHbuuuqGuq8B9dgOJuT043vMoa3CdOoBpfWA2qPYUqqBS7ahjXfgpQDbxlABusNaGJIKWKnltENOq4UBbUOXq1TVetUVa6fwasqtx1v_afFgHbXtE066ydbXSej-y5qb1zaYQ0ILqHO2MUGwxzau8OoknHo8wVcRDMqG9zXc3wAU9mfVA</recordid><startdate>19910701</startdate><enddate>19910701</enddate><creator>Furin, Mark J.</creator><creator>Norman, Philip S.</creator><creator>Creticos, Peter S.</creator><creator>Proud, David</creator><creator>Kagey-Sobotka, Anne</creator><creator>Lichtenstein, Lawrence M.</creator><creator>Naclerio, Robert M.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19910701</creationdate><title>Immunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity</title><author>Furin, Mark J. ; Norman, Philip S. ; Creticos, Peter S. ; Proud, David ; Kagey-Sobotka, Anne ; Lichtenstein, Lawrence M. ; Naclerio, Robert M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-6c03dfd6e09551dd9a5ce350292c8edb3dbd340617d7710e84ff24040936a0c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Allergic diseases</topic><topic>allergic rhinitis</topic><topic>Amb a I</topic><topic>Antigens - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Cell Movement - immunology</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>eosinophils</topic><topic>Eosinophils - immunology</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Immunotherapy</topic><topic>Leukocyte Count</topic><topic>Medical sciences</topic><topic>Nasal Cavity - immunology</topic><topic>Nasal Provocation Tests</topic><topic>Pollen - immunology</topic><topic>ragweed</topic><topic>Respiratory and ent allergic diseases</topic><topic>Rhinitis, Allergic, Seasonal - immunology</topic><topic>Rhinitis, Allergic, Seasonal - therapy</topic><topic>Seasons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furin, Mark J.</creatorcontrib><creatorcontrib>Norman, Philip S.</creatorcontrib><creatorcontrib>Creticos, Peter S.</creatorcontrib><creatorcontrib>Proud, David</creatorcontrib><creatorcontrib>Kagey-Sobotka, Anne</creatorcontrib><creatorcontrib>Lichtenstein, Lawrence M.</creatorcontrib><creatorcontrib>Naclerio, Robert M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furin, Mark J.</au><au>Norman, Philip S.</au><au>Creticos, Peter S.</au><au>Proud, David</au><au>Kagey-Sobotka, Anne</au><au>Lichtenstein, Lawrence M.</au><au>Naclerio, Robert M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>1991-07-01</date><risdate>1991</risdate><volume>88</volume><issue>1</issue><spage>27</spage><epage>32</epage><pages>27-32</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>We investigated the effect of immunotherapy (IT) on eosinophil (EOS) migration into the nasal cavity after nasal provocation with ragweed antigen and during seasonal exposure. In the first study, three groups of subjects participated: one group with no treatment (N = 19), one group with 10 months of IT, reaching maintenance at 2 μg of
Arab a I (antigen E) (N = 15), and one group with 22 months of IT, reaching maintenance at 24 μg of
Amb a I (N = 10). The percent of EOSs in nasal lavages performed during December before and 24 hours after nasal challenge with ragweed extract was determined. No significant difference between groups existed before challenge. The no-treatment group demonstrated a significant increase in the percent of EOSs from 26% to 69.5%
p < 0.008), whereas the treated groups demonstrated no significant change. In the second study, 45 patients were divided into four groups based on maintenance dose in micrograms of
Amb a I and duration of treatment: (1) no treatment (N = 15), (2) 1 year at 2 μg (N = 13), (3) 2 years at 2 μg (N = 11), and (4) 3 years at 24 μg (N = 9). Nasal mucosal brushings were done during the ragweed season. A significantly smaller percentage of EOSs in 3-year IT-treated individuals was obtained compared to the control group (18 versus 8.4;
p < 0.04). The smaller dose of IT, regardless of duration, did not reveal a reduction compared to that in the no-treatment group. These studies provide evidence that IT modifies the eosinophilic response to antigen exposure and demonstrate a parallel between in vivo provocation and seasonal exposure.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>2071783</pmid><doi>10.1016/0091-6749(91)90297-2</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of allergy and clinical immunology, 1991-07, Vol.88 (1), p.27-32 |
| issn | 0091-6749 1097-6825 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Allergic diseases allergic rhinitis Amb a I Antigens - administration & dosage Biological and medical sciences Cell Movement - immunology Dose-Response Relationship, Immunologic eosinophils Eosinophils - immunology Humans Immunopathology Immunotherapy Leukocyte Count Medical sciences Nasal Cavity - immunology Nasal Provocation Tests Pollen - immunology ragweed Respiratory and ent allergic diseases Rhinitis, Allergic, Seasonal - immunology Rhinitis, Allergic, Seasonal - therapy Seasons |
| title | Immunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity |
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