EXPERIMENTAL AND CLINICAL EVALUATION OF T-1982 (CEFBUPERA ZONE) IN THE FIELD OF OBSTETRICS AND GYNECOLOGY

Experimental and clinical studies of T-1982 (cefbuperazone), a new cephamycin antibiotic, were performed in the field of obstetrics and gynecology, and the following results were observed. 1. T-1982 was determined for its in vitro activity against 180 recent clinical isolates in comparison with cefmetazole (CMZ) and cefazolin (CEZ). The activity of T-1982 was superior to that of CMZ against E. coli (101 strains) and B. fragilis (19 strains), and similar to that of CMZ and CEZ against Peptococcus (34 strains). 2. High concentrations of T-1982 exceeding the MIC values against various bacteria were maintained for a few hours in the female genital organs and postoperative retroperitoneal exudate after intravenous drip infusion of 2g. 3. T-1982 was administered to a total of 6 patients in daily dose of 2-3g for 2-10 days. The clinical results were excellent or good in 5 cases. Drug eruption was observed in 1 case. These results suggest that T-1982 is highly effective for the treatment of bacterial infections in this field.