Spleen cell-mediated suppression of IgG production to a non-parasite antigen during chronic Trypanosoma cruzi infection in mice

Trypanosoma cruzi, mice, suppression of IgM responses to T cell-dependent (TNP-BGG) and T cell-independent (TNP-Ficoll) antigens during acute infection with return to normal levels during chronic phase, prolonged suppression of IgG responses to TNP-BGG during chronic infection, this suppression was...

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Veröffentlicht in:	The Journal of immunology (1950) 1983-10, Vol.131 (4), p.1978-1982
Hauptverfasser:	Reed, S.G, Roters, S.B, Goidl, E.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody-Producing Cells - immunology Antigens - administration & dosage Antigens - immunology Antilymphocyte Serum - administration & dosage Biological and medical sciences Chagas Disease - immunology Chagas Disease - parasitology Chronic Disease Experimental protozoal diseases and models Hemolytic Plaque Technique immune response immunocompetence Immunoglobulin G - biosynthesis immunoglobulins Infectious diseases Lymphocyte Activation Medical sciences Mice Mice, Inbred C57BL Parasitic diseases Protozoal diseases Spleen - cytology suppressor cells T-Lymphocytes, Regulatory - immunology Trinitrobenzenesulfonic Acid - administration & dosage Trinitrobenzenesulfonic Acid - immunology Trypanosoma cruzi
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Beschreibung
Zusammenfassung:	Trypanosoma cruzi, mice, suppression of IgM responses to T cell-dependent (TNP-BGG) and T cell-independent (TNP-Ficoll) antigens during acute infection with return to normal levels during chronic phase, prolonged suppression of IgG responses to TNP-BGG during chronic infection, this suppression was transferred with Thy-1.2-positive spleen cells
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.131.4.1978