Studies on antinephritic effect of Lipo PGE1 (1) Effect of Lipo PGE1 on crescentic-type anti-GBM nephritis in rats

The present study was designed to examine the antinephritic effect of Lipo PGE1 on crescentic-type anti-glomerular basement membrane (anti-GBM) nephritis in rats. Lipo PGE1i given i. v. twice a day at 2080 g/kg from the day after the anti-GBM serum injection (the 1st day), remarkably inhibited the urinary protein excretion as wall as glo merular histopathological changes such as crescent formation, adhesion of capillary walls to Bowman's capsule, and fibrinoid necrosis. Lipo PGE1 at doses, which the antinephritic action was recognized, significantly inhibited the elevation of platlet aggregation in renal vein and the decrease of renal blood flow. In addition, Lipo PGE1 significantly inhibited the elevation of plasma antibody titer against rabbit .A-globulin the apparently reduced the deposition of rat IgG in glomeruli. These results suggest that intravenous Lipo PGE1 may be useful for the treatment of rapidly progressive glomerulonephritis and this agent may mainly exert the antinephritic action by reducing the deposition of immune complex in glomeruli via the suppression of host antibody formation . Furthermore, the inhibition of platelet aggregation and the increase in renal blood flow by Lipo PGE1 may be also in part related to the antinephritic action of this agent.