A polymer carrier system for taste masking of macrolide antibiotics

A polymer carrier system was developed to reduce the bitterness of erythromycin and its 6-O-methyl derivative, clarithromycin, by absorption to Carbopol. The mechanism involves ionic bonding of the amine macrolide to the high molecular weight polyacrylic acid, thereby removing the drug from the solu...

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Veröffentlicht in:	Pharmaceutical research 1991-06, Vol.8 (6), p.706-712
Hauptverfasser:	MOU-YING FU LU, BORODKIN, S, WOODWARD, L, PING LI, DIESNER, C, HERNANDEZ, L, VADNERE, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Acrylic Resins Animals Anti-Bacterial Agents Biological and medical sciences Biological Availability Clarithromycin Dogs Drug Carriers Erythromycin - analogs & derivatives General pharmacology Humans Medical sciences Methylcellulose - analogs & derivatives Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyvinyls Taste
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