Endotoxin treatment of pregnant rats affects sexual behavior of the male offspring

The offspring of endotoxin-infused pregnant rats (0.2 μg endotoxin, 53.3 min, day 18 of pregnancy) did not exhibit different behavior in the Hebb-Williams-type maze test, but the males showed aberrations in the sexual behavior test. Because endotoxin did not cross the placental barrier, it was concl...

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Veröffentlicht in:	Physiology & behavior 1991-03, Vol.49 (3), p.647-649
Hauptverfasser:	Wijkstra, S., Valkhof, N., Koolhaas, J.M., Schuiling, G.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Copulation - drug effects Ejaculation - drug effects Embryology: invertebrates and vertebrates. Teratology Endotoxin Endotoxins - pharmacokinetics Endotoxins - pharmacology Escherichia coli Female Fundamental and applied biological sciences. Psychology Male Maternal-Fetal Exchange - drug effects Maze test Offspring Placental damage Pregnancy Prenatal Exposure Delayed Effects Rat Rats Sex Differentiation - drug effects Sexual behavior Sexual Behavior, Animal - drug effects Sexual Maturation - drug effects Teratology. Teratogens
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Zusammenfassung:	The offspring of endotoxin-infused pregnant rats (0.2 μg endotoxin, 53.3 min, day 18 of pregnancy) did not exhibit different behavior in the Hebb-Williams-type maze test, but the males showed aberrations in the sexual behavior test. Because endotoxin did not cross the placental barrier, it was concluded that the effect reflects abnormal brain development, caused by endotoxin-induced placental malfunction, notably impaired oxygen transport.
ISSN:	0031-9384 1873-507X
DOI:	10.1016/0031-9384(91)90294-X