Anti-gD monoclonal antibodies inhibit cell fusion induced by herpes simplex virus type 1
Monoclonal antibodies directed against glycoprotein D of herpes simplex virus completely inhibited fusion of Vero cells infected with type 1 virus. In contrast, several monoclonal antibodies directed against other viral glycoproteins, including B, were ineffective or were only minimally inhibitory a...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 1983-01, Vol.129 (1), p.218-224 |
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| container_end_page | 224 |
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| container_issue | 1 |
| container_start_page | 218 |
| container_title | Virology (New York, N.Y.) |
| container_volume | 129 |
| creator | Noble, A.Gwendolyn Lee, Gloria T-Y. Sprague, Robert Parish, Mary Lynn Spear, Patricia G. |
| description | Monoclonal antibodies directed against glycoprotein D of herpes simplex virus completely inhibited fusion of Vero cells infected with type 1 virus. In contrast, several monoclonal antibodies directed against other viral glycoproteins, including B, were ineffective or were only minimally inhibitory at the highest concentrations tested. |
| doi_str_mv | 10.1016/0042-6822(83)90409-9 |
| format | Article |
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Economical aspects</subject><subject>Microbiology</subject><subject>Production of active biomolecules</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>Simplexvirus - physiology</subject><subject>Vaccins</subject><subject>Viral Fusion Proteins</subject><subject>Viral Proteins - immunology</subject><subject>Viral Proteins - physiology</subject><subject>Virology</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAQgC0EKkvhH4DkA0JwSBnHqWNfKlUFSqVKXEDiZvkxpkZJHOykYv893u5qj_Q0mplvHvoIec3gjAETHwG6thGybd9L_kFBB6pRT8iGgRIN8I49JZsj8py8KOU31Lzv4YScCM5AStiQn5fTEptfn-iYpuSGNJmBmlqyyUcsNE530caFOhwGGtYS01RrfnXoqd3SO8xzpUoc5wH_0vuY10KX7YyUvSTPghkKvjrEU_Ljy-fvV1-b22_XN1eXt43rWL80UkoL0gA65oNwwE0Hrg3oZPDnFoPo0Qvr0aI30vbQehUkMCO54lI5yU_Ju_3eOac_K5ZFj7Hs3jUTprVoCaKT6vxxkHHRM867CnZ70OVUSsag5xxHk7eagd6Z1zuteqdVS64fzGtVx94c9q92RH8cOqiu_beHvinODCGbycVyxBTvAR6uX-wxrNLuI2ZdXMSpCo8Z3aJ9iv__4x_KRp__</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Noble, A.Gwendolyn</creator><creator>Lee, Gloria T-Y.</creator><creator>Sprague, Robert</creator><creator>Parish, Mary Lynn</creator><creator>Spear, Patricia G.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19830101</creationdate><title>Anti-gD monoclonal antibodies inhibit cell fusion induced by herpes simplex virus type 1</title><author>Noble, A.Gwendolyn ; Lee, Gloria T-Y. ; Sprague, Robert ; Parish, Mary Lynn ; Spear, Patricia G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-888b08a0ec1df6c03a40c2fec8fd5bef67ed6bdebeda8b702d9f801a839389c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Cell Fusion</topic><topic>Cell Line</topic><topic>Cercopithecus aethiops</topic><topic>Fundamental and applied biological sciences. 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| fulltext | fulltext |
| identifier | ISSN: 0042-6822 |
| ispartof | Virology (New York, N.Y.), 1983-01, Vol.129 (1), p.218-224 |
| issn | 0042-6822 1096-0341 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80648958 |
| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antibodies, Monoclonal Biological and medical sciences Biotechnology Cell Fusion Cell Line Cercopithecus aethiops Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry herpes simplex virus 1 Industrial applications and implications. Economical aspects Microbiology Production of active biomolecules Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Simplexvirus - physiology Vaccins Viral Fusion Proteins Viral Proteins - immunology Viral Proteins - physiology Virology |
| title | Anti-gD monoclonal antibodies inhibit cell fusion induced by herpes simplex virus type 1 |
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