Anti-gD monoclonal antibodies inhibit cell fusion induced by herpes simplex virus type 1

Monoclonal antibodies directed against glycoprotein D of herpes simplex virus completely inhibited fusion of Vero cells infected with type 1 virus. In contrast, several monoclonal antibodies directed against other viral glycoproteins, including B, were ineffective or were only minimally inhibitory a...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1983-01, Vol.129 (1), p.218-224
Hauptverfasser:	Noble, A.Gwendolyn, Lee, Gloria T-Y., Sprague, Robert, Parish, Mary Lynn, Spear, Patricia G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Biological and medical sciences Biotechnology Cell Fusion Cell Line Cercopithecus aethiops Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry herpes simplex virus 1 Industrial applications and implications. Economical aspects Microbiology Production of active biomolecules Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Simplexvirus - physiology Vaccins Viral Fusion Proteins Viral Proteins - immunology Viral Proteins - physiology Virology
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Beschreibung
Zusammenfassung:	Monoclonal antibodies directed against glycoprotein D of herpes simplex virus completely inhibited fusion of Vero cells infected with type 1 virus. In contrast, several monoclonal antibodies directed against other viral glycoproteins, including B, were ineffective or were only minimally inhibitory at the highest concentrations tested.
ISSN:	0042-6822 1096-0341
DOI:	10.1016/0042-6822(83)90409-9