Pharmacokinetics of stobadin and of the sum of its metabolites in rats during repeated administration

Stobadin dihydrochloride was administered p.o. to rats at a dose of 1 mg kg−1 once daily for 25 consecutive days. The peak and trough concentrations of the sum of stobadin metabolites, determined from Days 6–16 of treatment, demonstrated a steady‐state. The mean daily excretion of 3H‐radioactivity during this period was 43 per cent and 52 per cent of the administered dose into urine and faeces, respectively. The terminal half‐life of stobadin in plasma following a 25‐day chronic treatment was 78·3 min, which was shorter than the value of 95·3 min, determined in a single dose experiment. The data indicate that no accumulation of stobadin and of its labelled metabolites occurs in the course of repeated administration of 3H‐stobadin.