Hormonal regulation of pig Leydig cells in culture

Using a primary culture of purified immature pig Leydig cells, the hormonal and non hormonal regulation of steroidogenic activity have been studied. The effects of LH/hCG, FSH, LHRH, o-prolactin, estradiol, epidermal growth factor (EGF), human low density lipoprotein (hLDL) and human high density li...

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Veröffentlicht in:	Journal of steroid biochemistry 1983-07, Vol.19 (1A), p.375-384
Hauptverfasser:	Saez, J M, Benahmed, M, Reventos, J, Bommelaer, M C, Monbrial, C, Haour, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Chorionic Gonadotropin - pharmacology Epidermal Growth Factor - pharmacology Estradiol - pharmacology Follicle Stimulating Hormone - pharmacology Gonadotropin-Releasing Hormone - pharmacology Hormones - pharmacology Humans Kinetics Leydig Cells - drug effects Leydig Cells - physiology Lipoproteins - pharmacology Luteinizing Hormone - pharmacology Male Prolactin - pharmacology
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Beschreibung
Zusammenfassung:	Using a primary culture of purified immature pig Leydig cells, the hormonal and non hormonal regulation of steroidogenic activity have been studied. The effects of LH/hCG, FSH, LHRH, o-prolactin, estradiol, epidermal growth factor (EGF), human low density lipoprotein (hLDL) and human high density lipoprotein (hHDL) on 125I-hCG binding and basal and hCG-stimulated cAMP and steroids (testosterone and dehydroepiandrosterone sulfate) production were evaluated. These data on the regulation of pig Leydig cell activity are compared with other published results, mainly in the rat model, obtained either in vivo and in vitro.
ISSN:	0022-4731
DOI:	10.1016/S0022-4731(83)80050-8