The (CA + MG)-Atpase of reticulocytes

Rabbits were made reticulocytotic by repeated bleeding or by injection of phenylhydrazine. Up to reticulocyte levels of 70%, the baseline activity of magnesium- dependent calcium-stimulated adenosine triphosphatase ((Ca + Mg)-ATPase, EC 3.6.1.3) of the red cell plasma membrane was not significantly...

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Veröffentlicht in:	Life sciences (1973) 1983-08, Vol.33 (9), p.841-846
Hauptverfasser:	Cameron, Bruce F., Green, Loretta
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Bloodletting Ca(2+) Mg(2+)-ATPase Calcium - pharmacology Calcium-Transporting ATPases - blood Calmodulin - pharmacology Egtazic Acid - pharmacology Enzymes and enzyme inhibitors Erythrocyte Membrane - enzymology Female Fundamental and applied biological sciences. Psychology Hydrolases Phenylhydrazines - pharmacology Rabbits Reticulocytes - drug effects Reticulocytes - enzymology
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Beschreibung
Zusammenfassung:	Rabbits were made reticulocytotic by repeated bleeding or by injection of phenylhydrazine. Up to reticulocyte levels of 70%, the baseline activity of magnesium- dependent calcium-stimulated adenosine triphosphatase ((Ca + Mg)-ATPase, EC 3.6.1.3) of the red cell plasma membrane was not significantly changed. Maximal activity in the presence of calmodulin was significantly reduced, the stimulation by the activator falling from about 350% to about 50%.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(83)90622-7