Intense immunoreactivity for Mn-superoxide dismutase (Mn-SOD) in cholinergic and non-cholinergic neurons in the rat basal forebrain
The immunohistochemical localization of manganese (Mn)-superoxide dismutase (Mn-SOD) was studied in the rat basal forebrain using polyclonal antibodies to Mn-SOD. Neurons of the basal forebrain exhibit a high density of Mn-SOD immunoreactivity. Double immunostaining with a monoclonal antibody to cho...
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| Veröffentlicht in: | Brain research 1991-02, Vol.541 (2), p.354-357 |
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| creator | Inagaki, S. Takagi, H. Suzuki, K. Akai, F. Taniguchi, N. |
| description | The immunohistochemical localization of manganese (Mn)-superoxide dismutase (Mn-SOD) was studied in the rat basal forebrain using polyclonal antibodies to Mn-SOD. Neurons of the basal forebrain exhibit a high density of Mn-SOD immunoreactivity. Double immunostaining with a monoclonal antibody to choline acetyltransferase demonstrated that both cholinergic and non-cholinergic neurons in the basal forebrain are intensely immunoreactive for Mn-SOD. |
| doi_str_mv | 10.1016/0006-8993(91)91038-3 |
| format | Article |
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Neurons of the basal forebrain exhibit a high density of Mn-SOD immunoreactivity. Double immunostaining with a monoclonal antibody to choline acetyltransferase demonstrated that both cholinergic and non-cholinergic neurons in the basal forebrain are intensely immunoreactive for Mn-SOD.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(91)91038-3</identifier><identifier>PMID: 2054647</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Basal forebrain ; Biochemistry and metabolism ; Biological and medical sciences ; Central nervous system ; Choline acetyltransferase ; Choline O-Acetyltransferase - immunology ; Electrophoresis, Polyacrylamide Gel ; Fluorescent Antibody Technique ; Fundamental and applied biological sciences. Psychology ; Immunoblotting ; Immunohistochemistry ; Male ; Mn-superoxide dismutase ; Neurons - enzymology ; Neurons - immunology ; Parasympathetic Nervous System - enzymology ; Parasympathetic Nervous System - ultrastructure ; Rat ; Rats ; Rats, Inbred Strains ; Superoxide Dismutase - immunology ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1991-02, Vol.541 (2), p.354-357</ispartof><rights>1991 Elsevier Science Publishers B.V. 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Neurons of the basal forebrain exhibit a high density of Mn-SOD immunoreactivity. Double immunostaining with a monoclonal antibody to choline acetyltransferase demonstrated that both cholinergic and non-cholinergic neurons in the basal forebrain are intensely immunoreactive for Mn-SOD.</description><subject>Animals</subject><subject>Basal forebrain</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Choline acetyltransferase</subject><subject>Choline O-Acetyltransferase - immunology</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunoblotting</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Mn-superoxide dismutase</subject><subject>Neurons - enzymology</subject><subject>Neurons - immunology</subject><subject>Parasympathetic Nervous System - enzymology</subject><subject>Parasympathetic Nervous System - ultrastructure</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Superoxide Dismutase - immunology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9PFTEUxRsjgSf6DTTpRgKL0Xba6bQbEoLyJ8GwUNdNp70jNTPts-0QWPPFmfG9ACtd3fSe3z23uQeh95R8ooSKz4QQUUml2KGiR4oSJiv2Cq2obOtK1Jy8RqsnZA-9yfn3_GRMkV20W5OGC96u0MNlKBAyYD-OU4gJjC3-1pd73MeEv4UqT2tI8c47wM7ncSpmhg9n4fv1lyPsA7Y3cfAB0i9vsQkOhxiql70AU4ohL2i5AZxMwZ3JZlgWQJeMD2_RTm-GDO-2dR_9PPv64_Siuro-vzw9uaosY6xUjtbMKebqtqNO0a7jNQgOkhHa9pZz53hdc9YoQowERnhrZS9701guWyMs20cHG991in8myEWPPlsYBhMgTllLIth8F_JfkDZSKqEWkG9Am2LOCXq9Tn406V5TopeQ9JKAXhLQiuq_IWk2j33Y-k_dCO5paJvKrH_c6iZbM_TJBOvzs7cSQkrWzNzxhoP5arceks7WQ7DgfAJbtIv-3x95BHfyrqg</recordid><startdate>19910215</startdate><enddate>19910215</enddate><creator>Inagaki, S.</creator><creator>Takagi, H.</creator><creator>Suzuki, K.</creator><creator>Akai, F.</creator><creator>Taniguchi, N.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19910215</creationdate><title>Intense immunoreactivity for Mn-superoxide dismutase (Mn-SOD) in cholinergic and non-cholinergic neurons in the rat basal forebrain</title><author>Inagaki, S. ; Takagi, H. ; Suzuki, K. ; Akai, F. ; Taniguchi, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-d123d93d27b1d91bb42e64e83017fc44dd422435900a8e3047c8f8fa5c487a6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Basal forebrain</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Choline acetyltransferase</topic><topic>Choline O-Acetyltransferase - immunology</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Fluorescent Antibody Technique</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunoblotting</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Mn-superoxide dismutase</topic><topic>Neurons - enzymology</topic><topic>Neurons - immunology</topic><topic>Parasympathetic Nervous System - enzymology</topic><topic>Parasympathetic Nervous System - ultrastructure</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Superoxide Dismutase - immunology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inagaki, S.</creatorcontrib><creatorcontrib>Takagi, H.</creatorcontrib><creatorcontrib>Suzuki, K.</creatorcontrib><creatorcontrib>Akai, F.</creatorcontrib><creatorcontrib>Taniguchi, N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inagaki, S.</au><au>Takagi, H.</au><au>Suzuki, K.</au><au>Akai, F.</au><au>Taniguchi, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intense immunoreactivity for Mn-superoxide dismutase (Mn-SOD) in cholinergic and non-cholinergic neurons in the rat basal forebrain</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1991-02-15</date><risdate>1991</risdate><volume>541</volume><issue>2</issue><spage>354</spage><epage>357</epage><pages>354-357</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The immunohistochemical localization of manganese (Mn)-superoxide dismutase (Mn-SOD) was studied in the rat basal forebrain using polyclonal antibodies to Mn-SOD. Neurons of the basal forebrain exhibit a high density of Mn-SOD immunoreactivity. Double immunostaining with a monoclonal antibody to choline acetyltransferase demonstrated that both cholinergic and non-cholinergic neurons in the basal forebrain are intensely immunoreactive for Mn-SOD.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2054647</pmid><doi>10.1016/0006-8993(91)91038-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | Brain research, 1991-02, Vol.541 (2), p.354-357 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Basal forebrain Biochemistry and metabolism Biological and medical sciences Central nervous system Choline acetyltransferase Choline O-Acetyltransferase - immunology Electrophoresis, Polyacrylamide Gel Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Immunoblotting Immunohistochemistry Male Mn-superoxide dismutase Neurons - enzymology Neurons - immunology Parasympathetic Nervous System - enzymology Parasympathetic Nervous System - ultrastructure Rat Rats Rats, Inbred Strains Superoxide Dismutase - immunology Vertebrates: nervous system and sense organs |
| title | Intense immunoreactivity for Mn-superoxide dismutase (Mn-SOD) in cholinergic and non-cholinergic neurons in the rat basal forebrain |
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