Intense immunoreactivity for Mn-superoxide dismutase (Mn-SOD) in cholinergic and non-cholinergic neurons in the rat basal forebrain

The immunohistochemical localization of manganese (Mn)-superoxide dismutase (Mn-SOD) was studied in the rat basal forebrain using polyclonal antibodies to Mn-SOD. Neurons of the basal forebrain exhibit a high density of Mn-SOD immunoreactivity. Double immunostaining with a monoclonal antibody to cho...

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Veröffentlicht in:	Brain research 1991-02, Vol.541 (2), p.354-357
Hauptverfasser:	Inagaki, S., Takagi, H., Suzuki, K., Akai, F., Taniguchi, N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basal forebrain Biochemistry and metabolism Biological and medical sciences Central nervous system Choline acetyltransferase Choline O-Acetyltransferase - immunology Electrophoresis, Polyacrylamide Gel Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Immunoblotting Immunohistochemistry Male Mn-superoxide dismutase Neurons - enzymology Neurons - immunology Parasympathetic Nervous System - enzymology Parasympathetic Nervous System - ultrastructure Rat Rats Rats, Inbred Strains Superoxide Dismutase - immunology Vertebrates: nervous system and sense organs
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Zusammenfassung:	The immunohistochemical localization of manganese (Mn)-superoxide dismutase (Mn-SOD) was studied in the rat basal forebrain using polyclonal antibodies to Mn-SOD. Neurons of the basal forebrain exhibit a high density of Mn-SOD immunoreactivity. Double immunostaining with a monoclonal antibody to choline acetyltransferase demonstrated that both cholinergic and non-cholinergic neurons in the basal forebrain are intensely immunoreactive for Mn-SOD.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(91)91038-3