The role of penicillin amidases in nature and in industry

Penicillin amidase (PA) is the enzyme used commercially for the production of semisynthetic penicillins. During the past decase, a detailed picture of the structure and regulation of the gene encoding this enzyme has emerged, revealing a variety of interesting features that are unique among micrrorg...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 1991, Vol.16 (1), p.36-40
Hauptverfasser:	Valle, Fernando, Balba´s, Paulina, Merino, Enrique, Bollvar, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Escherichia coli - enzymology Gene Expression Regulation, Bacterial - physiology Genetic Engineering - methods penicillin Penicillin Amidase - genetics Penicillin Amidase - metabolism Protein Processing, Post-Translational - physiology Pseudomonas - enzymology reviews
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Penicillin amidase (PA) is the enzyme used commercially for the production of semisynthetic penicillins. During the past decase, a detailed picture of the structure and regulation of the gene encoding this enzyme has emerged, revealing a variety of interesting features that are unique among micrrorganisms. Clues to the biological role of this enzyme have been provided, as well as new strategies for the commercial production and utilization of PA.
ISSN:	0968-0004 1362-4326
DOI:	10.1016/0968-0004(91)90014-M