Nicotine exerts differential effects on different CA1 hippocampal cell types

The effects of (−) nicotine hydrogen tartrate (NHT) were examined on several cell types in the CA1 region of rat hippocampus. The results indicate that nicotine may have a preferential net inhibitory effect on basket cells and an excitatory effect on oriens/alveus interneurons. The resultant effects...

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Veröffentlicht in:	Brain research 1991-02, Vol.540 (1), p.287-290
Hauptverfasser:	Reece, Laura J., Schwartzkroin, Philip A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Animals Biological and medical sciences CA1 Dendrites - drug effects Dendrites - physiology Hippocampus - cytology Hippocampus - drug effects Hippocampus - physiology In Vitro Techniques Interneuron Interneurons - drug effects Interneurons - physiology Medical sciences Membrane Potentials - drug effects Nicotine Nicotine - pharmacology Pyramidal Tracts - cytology Pyramidal Tracts - drug effects Pyramidal Tracts - physiology Rat hippocampus Rats Tobacco, tobacco smoking Toxicology
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Zusammenfassung:	The effects of (−) nicotine hydrogen tartrate (NHT) were examined on several cell types in the CA1 region of rat hippocampus. The results indicate that nicotine may have a preferential net inhibitory effect on basket cells and an excitatory effect on oriens/alveus interneurons. The resultant effects of nicotine on pyramidal cells may thus be a product of complex local circuit interactions.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(91)90520-6