Pharmacological actions of substance P in the rat vas deferens

SP produces two different muscular responses in the isolated vas deferens of the rat. 1) A myotropic, post-synaptic effect that results from stimulation of one subtype of SP receptor, located on the membrane of the smooth muscle (NK-3 receptor). 2) A neurogenic effect at the pre-synaptic level that...

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Veröffentlicht in:	Neuropeptides (Edinburgh) 1991-04, Vol.18 (4), p.209-213
Hauptverfasser:	Miranda, H.F., Silva, W.I., Wolstenholme, W.W., Cuevas, N., Ucros, A., Bustamante, D., Fernández, E.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dose-Response Relationship, Drug Electric Stimulation Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Male Mammalian male genital system Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - innervation Muscle, Smooth - physiology Neurons - drug effects Rats Rats, Inbred Strains Receptors, Neurokinin-1 Receptors, Neurotransmitter - metabolism Substance P - pharmacology Synapses - drug effects Synaptic Transmission - drug effects Vas Deferens - drug effects Vertebrates: reproduction
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Zusammenfassung:	SP produces two different muscular responses in the isolated vas deferens of the rat. 1) A myotropic, post-synaptic effect that results from stimulation of one subtype of SP receptor, located on the membrane of the smooth muscle (NK-3 receptor). 2) A neurogenic effect at the pre-synaptic level that results from stimulation of another subtype of SP receptor, located on the nerve terminals (NK-1 receptor).
ISSN:	0143-4179 1532-2785
DOI:	10.1016/0143-4179(91)90149-D