Epithelioid sarcoma: a tumour of myofibroblasts

A case of epithelioid sarcoma of scalp has been studied by light and electron microscopy, histochemistry and immunocytochemistry. The results suggest that epithelioid sarcoma is a tumour of myofibroblasts. The epithelioid appearance results from gross and disordered accumulation of cytoplasmic inter...

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Veröffentlicht in:	Histopathology 1983-07, Vol.7 (4), p.573-584
Hauptverfasser:	BLEWITT, R.W., APARICIO, S.G.R., BIRD, C.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - analysis Adult Cell Nucleus - ultrastructure Cytoskeleton - ultrastructure Endoplasmic Reticulum - ultrastructure epithelioid sarcoma Epithelium - pathology Female Fibroblasts - pathology histochemistry Histocytochemistry Humans Intercellular Junctions - ultrastructure intermediate filaments myofibroblast Organoids - ultrastructure Sarcoma - analysis Sarcoma - pathology Scalp Skin Neoplasms - analysis Skin Neoplasms - pathology ultrastructure
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Beschreibung
Zusammenfassung:	A case of epithelioid sarcoma of scalp has been studied by light and electron microscopy, histochemistry and immunocytochemistry. The results suggest that epithelioid sarcoma is a tumour of myofibroblasts. The epithelioid appearance results from gross and disordered accumulation of cytoplasmic intermediate filaments (10 nm diameter), possibly of desmin type, producing the misleading light microscopical resemblance to epithelioid histiocytes and biphasic pattern of synovial sarcoma. The cause of the filament accumulation is unknown but it may represent a degenerative change leading to necrosis, a characteristic feature of epithelioid sarcoma.
ISSN:	0309-0167 1365-2559
DOI:	10.1111/j.1365-2559.1983.tb02269.x